New combo therapy shows promise for older AML patients

NCT ID NCT02835222

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether adding the drug selinexor to standard chemotherapy can help older adults with untreated acute myeloid leukemia (AML) live longer and achieve remission. About 57 participants will receive either standard chemo alone or chemo plus selinexor, followed by maintenance therapy. The goal is to see if the combination improves survival and reduces cancer growth.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Comprehensive Cancer Center of Wake Forest University

    Winston-Salem, North Carolina, 27157, United States

  • Virginia Commonwealth University Massey Cancer Center

    Richmond, Virginia, 23298, United States