Promising drug combo targets tough leukemia in early trial
NCT ID NCT03009240
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested a two-drug combination (pevonedistat plus decitabine) in 12 people with high-risk acute myeloid leukemia (AML), including those who had relapsed or couldn't tolerate standard chemo. The main goal was to find the safest dose and identify side effects. Researchers also looked at whether the treatment could shrink or eliminate cancer cells, but this was a small safety-focused trial, not a cure.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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City of Hope Medical Center
Duarte, California, 91010, United States
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