New coated nail aims to stop bone infections after leg fractures

NCT ID NCT05022485

Recruiting now Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new type of metal nail coated with a noble metal alloy to fix broken shin bones (tibia fractures). The goal is to see if it reduces the chance of infection compared to standard uncoated nails. About 500 adults with high-risk fractures will be followed for 12 months to check infection rates and bone healing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: noble metal alloy-coated intramedullary nail
What this could lead to: If it works, this could reduce the risk of serious bone infections after tibia fracture surgery, leading to faster healing and fewer complications.
What could go wrong: This is a mid-stage trial with a retrospective control group, which may introduce bias. The coating might not significantly lower infection rates, and there could be unknown risks with the new material.

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Conditions

The condition(s) this trial relates to.

tibia fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FRACTURE INFECTION TIBIAL FRACTURES

Contacts and locations

Locations

AOU Policlinico di Bari
RECRUITING

Bari, 70124, Italy
Azienda Ospedaliero-Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Groote Schuur Hospital
RECRUITING

Cape Town, 7935, South Africa
Hospital Universitario Valle de Hebrón
RECRUITING

Barcelona, Catalonia, 08035, Spain
Hôpital Ambroise-Paré
RECRUITING

Boulogne-Billancourt, 92100, France
Hôpitaux Universitaires de Marseille Nord
RECRUITING

Marseille, 13915, France
Kantonsspital Winterthur
RECRUITING

Winterthur, Canton of Zurich, 8400, Switzerland
King's College Hospital NHS Trust
RECRUITING

London, SE5 9RS, United Kingdom
Leeds General Infirmary
RECRUITING

Leeds, LS1 3EX, United Kingdom
Royal Infirmary of Edinburgh
RECRUITING

Edinburgh, EH16 4SA, United Kingdom
The Royal London Hospital
RECRUITING

London, E1 1FR, United Kingdom
Tirolkliniken Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Tygerberg Hospital
RECRUITING

Cape Town, 7505, South Africa
Universitätsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitätsklinikum Marburg
RECRUITING

Marburg, Hesse, 35039, Germany
Universitätsklinikum Regensburg
RECRUITING

Regensburg, 93053, Germany

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