Can a vacuum dressing stop infections in high-risk leg fractures?

NCT ID NCT06337292

Recruiting now Disease control Sponsor: Major Extremity Trauma Research Consortium Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk tibia fractures. Participants are randomly assigned to receive either the NPWT device or a regular dressing, and their recovery is tracked for 3 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: incisional negative pressure wound therapy (NPWT) device
What this could lead to: If it works, this could become a standard way to prevent wound infections and complications after high-risk fracture surgery.
What could go wrong: This is a mid-stage trial with 352 patients, so results may not apply to everyone. The device may not reduce infections significantly more than standard dressings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for FRACTURE OF TIBIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

injury tibia fracture Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FRACTURE OF TIBIA INFECTED WOUND WOUND COMPLICATION WOUND DEHISCENCE WOUND HEAL

Contacts and locations

Locations

Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Inova Fairfax MEdical Campus
RECRUITING

Falls Church, Virginia, 22042, United States
UTHealth/McGovern Medical School
RECRUITING

Houston, Texas, 77030, United States
University of Maryland R Adams Cowley Shock Trauma Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Maryland Shock Trauma/Capitol Regions
RECRUITING

Baltimore, Maryland, 21201, United States
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.