Can a vacuum dressing stop infections in high-risk leg fractures?
NCT ID NCT06337292
First seen May 17, 2026 · Last updated Jun 22, 2026 · Updated 8 times
Summary
This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk tibia fractures. Participants are randomly assigned to receive either the NPWT device or a regular dressing, and their recovery is tracked for 3 months.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dartmouth-Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
Contact
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Inova Fairfax MEdical Campus
RECRUITINGFalls Church, Virginia, 22042, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UTHealth/McGovern Medical School
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland R Adams Cowley Shock Trauma Center
RECRUITINGBaltimore, Maryland, 21201, United States
Contact
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University of Maryland Shock Trauma/Capitol Regions
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
incisional negative pressure wound therapy (NPWT) device
What this could lead to
If it works, this could become a standard way to prevent wound infections and complications after high-risk fracture surgery.
What could go wrong
This is a mid-stage trial with 352 patients, so results may not apply to everyone. The device may not reduce infections significantly more than standard dressings.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.