WOUND HEAL

This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk t…

This study tests a device that uses light and magnets (COMS) to help heal chronic leg ulcers. About 122 people with venous leg ulcers will receive either standard care plus COMS or standard care alone. The goal is to see if the device speeds up wound healing and improves quality …

This study tests guselkumab (Tremfya), a drug already used for psoriasis, in 17 adults with pyoderma gangrenosum—a rare disease that leads to painful, hard-to-heal skin ulcers. Participants receive injections every 4 weeks for 28 weeks. Researchers will check if ulcers heal compl…

This study tests a wireless, bioelectric bandage called PowerHeal™ on infected wounds. Researchers want to see if it clears infection and helps wounds close better than standard care. About 150 adults with infected traumatic wounds will take part. The bandage is changed regularly…

This trial tests whether a natural ointment called Xiang Lei Ointment can help heal diabetic ulcers better than standard care alone. The ointment aims to reduce inflammation and promote wound repair. The study will enroll 56 adults with diabetes and a foot or leg ulcer that is in…

This Phase 3 trial tests whether a gel called TR987, applied to the skin, can help heal chronic leg ulcers caused by poor blood flow. About 312 adults with venous leg ulcers will receive either the gel plus standard wound care or standard care alone. The main goal is to see if th…

This study tests whether a new gel containing hyaluronic acid and octenidine can improve gum healing after standard deep cleaning for periodontitis. About 26 adults with advanced gum disease will receive either cleaning alone or cleaning plus the gel. Researchers will measure hea…

This study tests whether a special dressing called EDX110, when added to standard care, helps diabetic foot ulcers heal faster and more completely. About 298 adults with a non-healing foot ulcer will be randomly assigned to receive either standard care alone or standard care plus…

This study tests a new antibacterial absorbable dressing on 30 adults with chronic non-healing wounds. The dressing is designed to break down in the body and help wounds heal faster. Researchers will measure how much the wound shrinks after 3 weeks and how many wounds fully close…

This phase 1/2 trial tests a topical treatment called Ev.FV, made from cell-derived particles, to help heal wounds in people with dystrophic epidermolysis bullosa (DEB), a genetic skin condition causing painful blisters. The study will enroll 20 participants with active wounds an…

This study looks at whether medical honey can help heal wounds in intensive care patients better than standard care. About 60 adults with fresh wounds (like pressure sores or cuts) will be randomly assigned to get either honey dressings or usual treatment. The main goal is to see…

This early study tests whether a new oxygen-delivery system using micro/nanobubbles can safely help heal different types of wounds. About 40 adults with acute or chronic wounds will receive either the oxygen bubbles or a standard saline treatment. Researchers will measure changes…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…