Tibia fracture

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This trial tests a new type of nail made from magnesium and titanium to fix broken leg or arm bones. The nail is designed to provide strong support while part of it gradually dissolves over time. Researchers will compare it to standard metal nails in 160 adults to see if it is ju…

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This phase 4 trial will test whether tranexamic acid (TXA), a drug that reduces bleeding, can safely lower blood loss in 200 orthopedic trauma patients who are on anticoagulants (blood thinners). Participants will have surgery for broken leg or thigh bones. The study compares tho…

This study tests whether an AI software called RBfracture helps clinicians better identify fractures, dislocations, and joint fluid buildup on X-rays. Sixteen doctors will review X-rays from 415 adult patients with and without the AI's help. The goal is to see if the AI improves …

This study tests a safety bundle—staff training, checklists, and audits—to prevent surgical site infections after emergency C-sections and open leg fracture repairs in Ethiopia. About 1,000 patients at public hospitals will be followed for 2 years to measure infection rates and d…

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This study compares two surgical methods for fixing a broken shinbone (tibia). One technique enters above the kneecap, the other from the side of the kneecap. Researchers will measure knee function, pain, and recovery in 40 adults aged 18-60. The goal is to find which approach le…

This study tests if using a floor pedal bike at home helps people recover from leg fractures and ankle injuries. Twenty adults with these injuries will get a bike at their first post-surgery visit and be asked to use it regularly. Researchers will track their physical activity an…

This early study tests whether applying nitroglycerin ointment (a medicine that widens blood vessels) to surgical wounds during high-risk leg surgeries can improve blood flow and reduce complications like infection or wound separation. Fifteen adults undergoing specific ankle, he…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study tests a device called the Verus frame, which supports the leg during surgery to fix a broken shinbone. The goal is to see if it helps surgeons align the bone more accurately. Twenty-five adults with tibial fractures will be enrolled, and their results will be compared …

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

This study looks at whether a small pressure sensor placed in the leg during surgery can help doctors spot a rare but serious problem called acute compartment syndrome. Teens aged 10 to 21 with a broken shinbone will have the sensor monitor pressure for at least 18 hours after th…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study tests whether a structured, supervised exercise program can help adults recover from serious leg fractures. About 40 people who had surgery for a broken thigh or shin bone will either do the exercise program or get usual care. The main goal is to see if the program is …

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This pilot study will use a very small camera, called a nano-arthroscope, to look inside the ankle joint of 25 people who have a severe type of ankle fracture (pilon fracture). The goal is to find out how often hidden cartilage injuries occur and whether seeing them changes the s…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study will look back at the medical records of about 2000 older adults (60+) who had surgery for a broken bone in Shanghai between 2010 and 2019. Researchers want to see how factors like age, nutrition, and which bone broke affect the risk of dying within 1, 3, or 5 years af…