Could a heart ointment help heal leg wounds after surgery?

NCT ID NCT07004764

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests whether applying nitroglycerin ointment (a medicine that widens blood vessels) to surgical wounds during high-risk leg surgeries can improve blood flow and reduce complications like infection or wound separation. Fifteen adults undergoing specific ankle, heel, or shinbone surgeries will receive the ointment, and blood flow will be measured with a special imaging system. The goal is to see if this simple approach is worth testing in larger trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
nitroglycerin ointment 2%
What this could lead to
If it works, this could point toward a simple way to improve wound healing and reduce infections after high-risk leg surgeries.
What could go wrong
This is a very small, early feasibility study with only 15 participants. It may not show a clear benefit, and nitroglycerin can cause side effects like headache or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Ankle Fractures Surgical Wound Dehiscence tibia fracture Tibial Plateau Fractures Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Johns Hopkins Bayview Medical Center

    Baltimore, Maryland, 21224, United States

  • The Johns Hopkins Hospital

    Baltimore, Maryland, 21201, United States

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