Could a heart ointment help heal leg wounds after surgery?
NCT ID NCT07004764
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tests whether applying nitroglycerin ointment (a medicine that widens blood vessels) to surgical wounds during high-risk leg surgeries can improve blood flow and reduce complications like infection or wound separation. Fifteen adults undergoing specific ankle, heel, or shinbone surgeries will receive the ointment, and blood flow will be measured with a special imaging system. The goal is to see if this simple approach is worth testing in larger trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nitroglycerin ointment 2%
What this could lead to
If it works, this could point toward a simple way to improve wound healing and reduce infections after high-risk leg surgeries.
What could go wrong
This is a very small, early feasibility study with only 15 participants. It may not show a clear benefit, and nitroglycerin can cause side effects like headache or low blood pressure.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins Bayview Medical Center
Baltimore, Maryland, 21224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Johns Hopkins Hospital
Baltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••