Johns Hopkins University

This study looks at whether starting strong medications early for relapsing-remitting multiple sclerosis (MS) works better than the usual step-up approach to prevent long-term disability. About 900 adults aged 18-60 with MS are taking part. Researchers are tracking disability pro…

This study tests a new, less invasive surgery for spina bifida performed while the baby is still in the womb. Instead of a large cut in the uterus, doctors use tiny tools and a camera (fetoscope) to close the spinal opening. The goal is to see if this approach works as well as op…

This study looks at whether psilocybin, a hallucinogenic drug, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21-65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression symptoms and drinking…

This study looks at how to improve HIV treatment for people who inject drugs in India. It tests three approaches: starting HIV medicine right away, getting care at community centers instead of government clinics, and offering extra support for those whose treatment isn't working.…

This study is testing a new device called a multichannel vestibular implant for people who have lost most of their balance function due to inner ear damage. The implant electrically stimulates the balance nerve to help improve stability and vision. Up to 30 adults with severe bal…

This study tests whether having a peer case manager helps people with HIV who also have mental health or substance use problems get the care they need. About 405 participants will be randomly assigned to usual care or to work with a peer who supports them in finding treatment. Th…

This study is for adult women living with HIV/AIDS who have also experienced intimate partner violence. Researchers are testing a program that combines trauma-informed care with a safety planning app to improve mental health, HIV management, and safety. The goal is to see if this…

This study tests a smartphone-based system to help community health workers support people with both TB and HIV in South Africa. The goal is to improve treatment success, reduce deaths, and keep patients engaged in care. The approach uses video directly observed therapy and other…

This study provided an experimental blood substitute called HBOC-201 to adults with life-threatening anemia who could not receive standard blood transfusions. The treatment is made from purified cow hemoglobin and helps carry oxygen to tissues without needing blood type matching.…

This study tests whether combining home blood pressure monitoring with support from community health workers helps adults with early high blood pressure keep it under control. About 600 adults from community health centers will either get a home monitor alone or the monitor plus …

This study tests an experimental drug called MW189 in 120 adults who have had a bleeding stroke (intracerebral hemorrhage). The goal is to see if the drug is safe and can reduce brain swelling, which often causes further damage. Participants receive the drug within 24 hours of th…

This study tests a procedure called FETO, where a tiny balloon is placed in the windpipe of a fetus to help the lungs grow before birth. It is for pregnant women carrying a baby with a severe left-sided diaphragmatic hernia, a condition where the diaphragm has a hole and organs m…

This study looks at whether it is safe for people with HIV to receive a liver transplant from a donor who also had HIV. The main goal is to check for serious problems like organ failure, infections, or HIV complications. About 80 participants are being followed to see how well th…

This study looks at adults with epilepsy who have been on a modified Atkins diet for at least a year and have high cholesterol. Researchers want to see if changing the diet or adding a statin can safely lower cholesterol without causing more seizures. The goal is to help doctors …

This study tests whether a brain shunt surgery helps people with idiopathic normal pressure hydrocephalus (iNPH), a condition that causes trouble walking and thinking. About 100 adults aged 60 and older will either get the real surgery or a placebo procedure. The main goal is to …

This study aimed to test a closed-loop spinal cord stimulation system to reduce muscle stiffness (spasticity) and pain in people who had a stroke or brain injury. The trial was withdrawn before enrolling any participants, so no results are available. The approach was intended to …

This phase 3 trial tests whether an oral antioxidant called N-acetylcysteine (NAC) can slow the loss of vision in people with retinitis pigmentosa, an inherited eye disease that causes blindness. About 485 adults aged 18 to 65 will take NAC or a placebo daily for 45 months. The s…

This study tests an experimental therapy for pregnant women whose babies have no amniotic fluid because of severe kidney problems. The treatment involves repeatedly adding sterile fluid into the womb to help the baby's lungs grow enough to survive after birth. The trial includes …

This study looks at whether having a nurse case manager helps people with multi-drug resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 adults in South Africa are involved. Half of the clinics have a nurse case manager, and the other half do not. T…

This study tests whether a daily pill called dapagliflozin can help adults with Fontan circulation, a heart condition from birth. Researchers want to see if it lowers pressure in the veins and improves exercise ability. About 29 adults will take the drug for 4 weeks and have chec…

This study aimed to see if adding a high dose of psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine treatment could help people with opioid use disorder stay off illicit opioids and improve their quality of life. It planned to compare a high dose (30 …

This study tests advanced ultrasound techniques to make breast images clearer. Researchers want to see if these methods can better show microcalcifications, cysts, and whether a mass is solid or fluid-filled. About 252 women with certain breast findings will participate. The goal…

This study tests whether collecting sexual health information electronically during routine gynecologist visits can help identify women who could benefit from HIV prevention medication (PrEP). About 1,170 women aged 15-65 attending well-woman exams will take part. The goal is to …

This study aims to see if a program called ACTFAST can help prevent firearm injuries by teaching safe storage and safety practices to patients admitted to trauma centers. About 1,776 adults from three hospitals will take part. Researchers will check if patients receive the progra…

This study enrolls 150 young women aged 13-25 in Baltimore who have pelvic inflammatory disease (PID). Some receive extra nurse home visits and text message support for 30 days to help them finish treatment and avoid unprotected sex. The goal is to see if this approach reduces re…

This study tests a new tool that helps doctors have better conversations with patients who have prediabetes. The tool uses a questionnaire to understand how ready a patient is to make healthy changes, then suggests resources like health coaches or diabetes prevention programs. Ab…

This study tests a training program for doctors at three children's trauma centers to help them talk with families about safe firearm storage. The goal is to prevent firearm injuries in children by increasing these conversations and providing resources. About 1,000 parents and te…

This study looks at whether using HEPA air purifiers at home can improve asthma symptoms in children aged 8 to 17. Researchers want to see if overweight children benefit more than lean children. About 200 kids from Baltimore with persistent asthma will take part. Half will get re…

This study tests whether combining music-based movement therapy (patterned sensory enhancement) with mild brain stimulation can improve arm and hand function in people with corticobasal syndrome, a rare brain disorder. Twenty adults will receive either music therapy alone or musi…

This study tests a program called PICU Up! that helps critically ill children start moving early during their stay in the pediatric intensive care unit (PICU). The program combines sleep support, delirium prevention, and less sedation to encourage safe mobility. Researchers want …

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having this surgery for non-cancer reasons will be randomly assigned to get a standard or reduced opioid prescription. The goal is t…

This study looks at whether taking tetracycline for 3 months is tolerable for people with Post-Treatment Lyme Disease (PTLD) — those who still have symptoms like fatigue after standard antibiotic treatment. About 60 adults aged 18–80 will receive either tetracycline or a placebo,…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can safely reduce PTSD symptoms in 20 adults who are already on antidepressant medication. Participants receive psilocybin in a controlled setting, and some also get trauma-focused talk the…

This study tests a standardized, high-intensity swallowing therapy program for adults who have trouble swallowing after an ischemic stroke. Researchers will enroll 60 participants in an acute rehab facility to see if the therapy improves swallowing safety and ability to eat by mo…

This study tests whether a low dose of ketamine, given through an IV, can help reduce fatigue in people with multiple sclerosis (MS). About 110 adults with MS who experience significant fatigue will receive either ketamine or an active placebo. The main goal is to see if ketamine…

This study gives 30 family child care providers and the parents they serve a digital toolkit with a tele-wellness service called "Ask a Nurse" to help manage stress and improve parenting. Children get access to fun learning games in reading, math, emotions, and nutrition. The goa…

This study tests whether an injection of hyaluronidase, a natural enzyme, can reduce muscle stiffness and improve movement in people who had a stroke. About 56 adults with moderate-to-severe arm stiffness will receive either the enzyme or a placebo, then switch to the other. The …

This study tests whether watching telenovela-style educational videos can reduce anxiety and boost confidence in African-American and Hispanic family members caring for hospice patients. 62 caregivers will either receive the video program plus usual hospice care or usual care alo…

This study tests whether a safe, painless brain stimulation technique called tDCS can improve memory and word learning in people with Alzheimer's disease. About 94 participants with either typical Alzheimer's or a language-focused form will receive either real or fake stimulation…

This study tests whether a gentle brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake tDCS for 30 minutes over 10 sessions. The goal is to see if the…

This study tests a hearing care program for older Korean Americans (age 60+) with hearing loss. The program includes a low-cost hearing device and rehabilitation, delivered in the community. Researchers want to see if it improves communication and quality of life compared to wait…

This study is creating a long-term registry of 2,000 people with gastroesophageal reflux disease (GERD) and related conditions like Barrett's esophagus. Researchers will collect information from medical records and questionnaires over 5 years to better understand how GERD is diag…

This study aims to find genes that cause inflammatory bowel disease (IBD) specifically in African Americans. Researchers will collect health information and a blood sample from 2,400 African American volunteers, both with and without IBD. The goal is to better understand the gene…

This study tests three new pulse oximeters (devices that measure oxygen levels) in 936 young children with breathing infections in Cape Town, South Africa. The goal is to see if these devices help healthcare workers correctly identify low oxygen and refer children for proper care…

This study looks at how data from wearable devices (like activity trackers and heart monitors) relates to heart and muscle function in people with a type of heart failure called HFpEF and those without it. Researchers will compare daily activity levels and other measurements betw…

This study looks at how getting older might change a person's ability to become aware of patterns in a simple learning task. Researchers used a mild electrical current to temporarily affect a part of the brain in 16 healthy adults aged 20-30. They then measured how well participa…

This study looks at how listening to personally meaningful music versus standard playlists changes the effects of psilocybin in healthy adults aged 21 to 75. One hundred participants will take a single dose of psilocybin, listen to different music conditions, and complete surveys…

This study screens 1500 adults for oral HPV infection and related antibodies to identify those at higher risk for HPV-related throat cancer. Researchers follow participants over time to see which infections persist and what factors (like mouth bacteria or immune response) play a …

This early-stage study tests whether a cream made from sulforaphane, a compound found in broccoli, can improve skin aging and protect against damage from sunlight and visible light. Researchers will measure changes in skin proteins linked to strength and aging in 12 adults. The g…

This study aims to find the genetic and environmental causes of inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers are enrolling 2,500 adults and children with IBD, their family members, and healthy volunteers for comparison. No t…

This study looks at whether placing a preterm baby on their belly (prone) or back during the 30-60 seconds of delayed cord clamping reduces the need for breathing tubes. About 89 very early preterm babies (born between 25-29 weeks) will be randomly assigned to one position. The g…

This study involves 150 people with relapsing-remitting multiple sclerosis (MS) and their doctors. The goal is to create a questionnaire that can confirm MS relapses without requiring an in-person visit, saving patients time and travel. Researchers will also test if better commun…

This study was designed to see if a new ultrasound device with a needle guide could help doctors safely insert needles into the femoral artery during liver cancer treatment. The study was withdrawn before any participants were enrolled, so no results are available. The goal was t…

This study looks at whether a computer-delivered alcohol intervention plus help from a community health worker can reduce heavy drinking and improve HIV prevention and care among women. About 12 women who drink heavily and either have HIV or are at risk for it will take part. The…

This study looks at whether a patient navigator—a person who helps guide patients through the healthcare system—can improve timely follow-up after an abnormal breast imaging result. The study includes 196 people who had an abnormal screening mammogram and had not yet completed di…

This study looks for early DNA changes in blood and tissue that might warn of esophageal cancer in people with Barrett's esophagus or chronic reflux. Researchers will follow 600 participants over time to see if these markers can predict cancer progression. The goal is to improve …

This study aimed to see if giving extra oxygen during sleep could improve blood sugar control in people living at high altitudes. It was designed for permanent residents of Puno, Peru, who have sleep-disordered breathing. However, the study was withdrawn before any participants w…

This study aims to better understand Cleidocranial Dysplasia (CCD), a rare genetic condition affecting bones and teeth. Researchers will collect medical history, quality-of-life surveys, and genetic samples from 300 participants to link genetic changes with physical symptoms. The…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) develops and progresses in this group. Researchers use a non-invasive ultrasound-like scan to measure liver fat and stiffness over one year. The goal is to fill major knowledge gaps, sinc…

This study follows 500 people with neurofibromatosis type 1 (NF1) to track how their skin tumors (cutaneous neurofibromas) grow and change over five years. Researchers use a special 3D camera to measure tumors without touching the skin. The goal is to better understand these tumo…

This study looks at whether trained community health workers can help Korean American elders with possible dementia and their caregivers. About 288 pairs (elder and caregiver) will either get the program or usual care. The goal is to see if the program helps elders get medical ca…

This study follows 80 people with neurofibromatosis type 1 (NF1) who are at high risk for developing malignant peripheral nerve sheath tumors (MPNST). Researchers will use yearly whole-body MRI scans, blood samples, and checkups to track changes in nerve tumors over time. The goa…

This study tests whether a comprehensive sexual education program in rural Madagascar middle schools can reduce violence and bullying among students. About 4,500 students, teachers, and directors from 50 schools will participate, with half the schools receiving the program and ha…

This study involves 95 adults with cancer-related fluid buildup around the lung who have a tunneled pleural catheter. Researchers want to learn why some patients stop producing fluid (pleurodesis) and how to predict it. They will measure a protein called TGF-B in the fluid over 1…

This study was designed to test whether tartrazine, a common food dye, can be applied to the skin to make it temporarily see-through, allowing doctors to view blood vessels and other structures underneath without surgery. It was planned for healthy adults and involved patch tests…

This study is testing a program called CONNECT that helps more women and Black and Latino adults learn about and join heart health research. About 1,000 people with heart disease or risk factors like high blood pressure or diabetes will receive text messages with heart health inf…

This study tests a diagnostic stewardship program in pediatric intensive care units to reduce how often respiratory cultures are taken from children on ventilators. The goal is to safely cut down on unnecessary antibiotic use. The study involves 15 hospitals and will measure chan…

This study collects blood and tissue samples from 360 people with early-stage liver cancer who have surgery to remove their tumors. Researchers look for patterns in the immune system and antibodies that might help predict if the cancer will come back. The goal is to find better w…

This study looks at whether giving families in rural Congo a youth-friendly economic program (raising rabbits) and a gender equality course for parents can improve the mental health of teens aged 10-14. Over 3,000 adolescents and their parents from 30 villages are taking part. Th…

This study collects information from patients who undergo a procedure called percutaneous cholangiopancreatoscopy, where a thin scope is used to look at and treat bile duct issues like stones or blockages. Researchers will track how many patients can have their drainage tube remo…

This study looks at how often acid reflux (GERD) happens in people with obesity after they have a weight-loss procedure, either surgery or an endoscopic treatment. Researchers will track 250 adults to see who develops GERD symptoms or silent reflux, where acid damages the esophag…

This study collects blood or skin samples from 100 adults with inherited heart rhythm conditions (like Long QT Syndrome or Brugada Syndrome) and healthy volunteers. Researchers will turn these samples into heart cells in a lab to study how the diseases work and test potential tre…

This study aims to better understand inflammatory bowel disease (IBD) by collecting tissue samples from 1,100 people undergoing endoscopy or bowel surgery. Researchers will analyze gene activity, proteins, and gut microbes to uncover what causes IBD. Participants include both peo…

This study aims to find new antibodies that may cause autoimmune gastrointestinal motility disorders, where the gut doesn't move food properly. Researchers will analyze blood samples from 300 people over age 13 with chronic gut symptoms. The goal is to better understand these con…

This study planned to see if delivering medically tailored meals to Black women after pregnancy could help them control weight and blood pressure. It focused on women who had high blood pressure during pregnancy and were low-income. The study was withdrawn before any participants…

This study is not a treatment trial but a large data project. Researchers at Johns Hopkins gathered anonymous cholesterol and other blood fat measurements from over 5 million patients who had a special blood test. The goal is to analyze this huge amount of information to find pat…

This study looks at how well people with sarcoidosis follow their medication routine and how that affects their disease. Researchers will follow 150 adults in Maryland and D.C. for one year, tracking lung function, symptoms, and hospital visits. The goal is to understand barriers…

This study looks at whether MRI scans are safe for people with pacemakers or implanted defibrillators without the usual strict pre-screening. Researchers will enroll up to 4,500 participants who need an MRI for medical reasons. The goal is to see if current safety rules can be re…

This study looks at how ketogenic diets (like the modified Atkins diet) impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. About 105 adults aged 18 and older who are already on or startin…

This study looks at whether a mobile health app can help living kidney donors complete their required follow-up visits after donating a kidney. About 400 donors will be randomly assigned to use the app or receive standard care. The goal is to see if the app improves compliance wi…

This study tests whether an educational program and mobile health tools can help adults with kidney failure find a living donor for a transplant. About 775 participants who haven't yet identified a donor will take part. The goal is to see if these tools increase the number of liv…

This study was designed to test a new metal nail (Artemis PFN) for repairing a common type of hip fracture. Researchers planned to compare results from patients who received this nail to past patients who got other implants. However, the study was withdrawn before enrolling anyon…

This study from Johns Hopkins University tests whether a video camera can accurately measure vital signs like blood oxygen levels, heart rate, and blood pressure. Researchers are recording 94 healthy adults to build a database of video and sensor data. The goal is to improve tele…

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain function and thinking in 15 healthy adults. Participants receive psilocybin in a controlled setting while their brain activity is measured with EEG and TMS. The goal is to understand how p…