Scientists build heart cells in a dish to unravel genetic heart disease

NCT ID NCT02413450

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study collects blood or skin samples from 100 adults with inherited heart rhythm disorders (like Long QT Syndrome or Brugada Syndrome) and healthy volunteers. Researchers will turn these samples into stem cells and then into heart cells to study how these diseases work and test potential treatments in the lab. The goal is to better understand these conditions, not to directly treat participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could lead to better understanding of inherited heart diseases and help test new treatments in the lab.
What could go wrong: This is an early-stage research study, not a treatment trial. It may not directly lead to new therapies, and lab models may not fully replicate human disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arrhythmogenic right ventricular cardiomyopathy Brugada syndrome cardiac rhythm disease cardiogenetic rhythm disorder catecholaminergic polymorphic ventricular tachycardia Channelopathies dilated cardiomyopathy Duchenne muscular dystrophy early repolarization associated with ventricular fibrillation hypertrophic cardiomyopathy long QT syndrome muscular dystrophy myotonic dystrophy Polymorphic Catecholaminergic Ventricular Tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARRHYTHMOGENIC CARDIOMYOPATHY (AC, ARVD/C) BRUGADA SYNDROME (BRS) CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT) DILATED CARDIOMYOPATHY (DCM) EARLY REPOLARIZATION SYNDROME (ERS) HYPERTROPHIC CARDIOMYOPATHY (HCM) INHERITED CARDIAC ARRYTHMIAS LONG QT SYNDROME (LQTS) MUSCULAR DYSTROPHIES (DUCHENNE, BECKER, MYOTONIC DYSTROPHY) NORMAL CONTROL SUBJECTS

Scientists build heart cells in a dish to unravel genetic heart disease

Summary

What this could mean

Get notified about this study

Conditions

As listed by the trial registrant

Contacts and locations

Locations

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