DILATED CARDIOMYOPATHY (DCM)
Clinical trials for DILATED CARDIOMYOPATHY (DCM) explained in plain language.
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Experimental cell therapy targets End-Stage heart disease
Disease control Recruiting nowThis early-stage trial tested a new cell therapy called CAR-DC in 8 people with end-stage dilated cardiomyopathy, a condition that weakens the heart. The therapy targets a protein called FAP to calm the immune system and improve heart function. The main goal was to check safety, …
Matched conditions: DILATED CARDIOMYOPATHY (DCM)
Phase: PHASE1, PHASE2 • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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One-Time gene infusion aims to repair hearts in rare genetic condition
Disease control Recruiting nowThis early-stage trial tests a single intravenous dose of AFTX-201, a gene therapy designed to deliver a working copy of the BAG3 gene to heart cells. It enrolls 22 adults aged 18–55 with dilated cardiomyopathy and a BAG3 mutation. The study primarily checks safety and tolerabili…
Matched conditions: DILATED CARDIOMYOPATHY (DCM)
Phase: PHASE1, PHASE2 • Sponsor: Affinia Therapeutics • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Second infusion of designer cells aims to rescue failing hearts
Disease control Recruiting nowThis early study tests whether a second infusion of a patient's own modified immune cells (CAR-DC) is safe and can improve heart function in 5 adults with end-stage dilated cardiomyopathy. Participants had already received one dose but saw their heart function worsen again. The g…
Matched conditions: DILATED CARDIOMYOPATHY (DCM)
Phase: PHASE1 • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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One-Time gene shot aims to mend broken hearts
Disease control Recruiting nowThis early-stage trial tests a one-time gene therapy called RP-A701 in 8 adults with dilated cardiomyopathy caused by a faulty BAG3 gene. The therapy uses a harmless virus to deliver a working copy of the gene, aiming to improve heart function. The main goal is to check safety, b…
Matched conditions: DILATED CARDIOMYOPATHY (DCM)
Phase: PHASE1 • Sponsor: Rocket Pharmaceuticals Inc. • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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5,000 heart patients to wear smart patches for Years-Long observation
Knowledge-focused Recruiting nowThis study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…
Matched conditions: DILATED CARDIOMYOPATHY (DCM)
Sponsor: Prolaio • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Heart tissue analysis aims to unlock better diagnosis
Knowledge-focused Recruiting nowThis study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns in different heart conditions, including after a heart transplant. The goal is to improve how these diseases are diagnosed …
Matched conditions: DILATED CARDIOMYOPATHY (DCM)
Sponsor: University Hospital, Essen • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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New heart MRI study could simplify diagnosis without dye
Knowledge-focused Recruiting nowThis study will use cardiac MRI scans to measure heart tissue in 2000 people with various heart conditions, such as heart attacks, cardiomyopathies, and myocarditis. The goal is to create a reference map of normal and abnormal tissue values, which may help doctors diagnose diseas…
Matched conditions: DILATED CARDIOMYOPATHY (DCM)
Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Can tiny heart vessel problems predict major cardiac events?
Knowledge-focused Recruiting nowThis study looks at how problems in the heart's tiny blood vessels (coronary microvascular dysfunction) affect long-term outcomes in people with dilated cardiomyopathy, a condition where the heart muscle is enlarged and weak. Researchers will follow 330 participants who have alre…
Matched conditions: DILATED CARDIOMYOPATHY (DCM)
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC