Johns Hopkins University

This study tests whether daridorexant, a medication that blocks certain brain signals related to wakefulness, can help people with alcohol use disorder who also have trouble sleeping. About 150 adults will receive either the drug or a placebo, and researchers will measure changes…

This study tests whether a program led by local health volunteers can improve lung health for 800 people in Bhaktapur, Nepal, who are at risk for chronic lung diseases like asthma or COPD. The program focuses on reducing tobacco and air pollution exposure, preventing infections, …

This study tests whether injecting steroids into the narrowed part of the windpipe after a dilation procedure can help people with idiopathic subglottic stenosis go longer without needing another surgery. About 226 adults will receive either steroid injections or a placebo right …

This study looks at whether using a low-sodium salt substitute is safe for adults with high blood pressure who are already on medication. About 607 people in Bangladesh will replace regular salt with the substitute for cooking and seasoning. Researchers will check if it causes da…

This study tests whether a natural sugar called N-acetylglucosamine (GlcNAc) can safely control Crohn's disease symptoms. It includes 40 adults with Crohn's disease affecting the ileum, some with a specific genetic change. Participants will receive GlcNAc or a placebo in two phas…

This study tests a program called iTHRIVE for 100 Black or Hispanic adults with high blood pressure living in areas with limited healthy food options. Participants get access to a digital food marketplace, personalized dietitian coaching, and a home blood pressure monitor. The go…

This study tests a new way to help Black and Hispanic women with high blood pressure by bringing health services right into beauty salons. Stylists will be trained to check blood pressure, and participants will get home monitoring, coaching, and pharmacist support. The goal is to…

This study looks at whether a new finger-stick test that gives hepatitis C results in about an hour is acceptable to emergency room patients. About 200 adults who have tested positive for hepatitis C antibodies but don't know if they have an active infection will be randomly assi…

This study tests whether an AI-powered stethoscope can help doctors in rural Bangladesh safely reduce antibiotic use in children with pneumonia. About 2,500 children will be randomly assigned to standard care or care guided by the AI stethoscope. The goal is to see if the AI tool…

This study looks at whether telling adults with prediabetes about their personal diabetes risk helps them take action to prevent the disease. About 120 participants will either have a 30-minute talk with a healthcare team member, receive a simple message through their patient por…

This early-stage study tests whether combining semaglutide (a diabetes drug) with naltrexone (a craving-reducing medication) can safely help people with alcohol use disorder drink less. About 45 adults in a residential treatment program will take the combo for 4 weeks. Researcher…

This study tests whether cannabidiol (CBD) can reduce withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. About 105 adults will stay in a hospital unit for 5 days, receive either CBD or a placebo alongside standard care, and have their withdra…

This early-stage study tests if a shortened LSD experience, combined with the drug risperidone, can safely ease symptoms of major depression. Ten adults with moderate to severe depression will receive LSD followed by risperidone 45 minutes later. Researchers will monitor safety a…

This study tests a personalized brain stimulation method for 10 people with primary progressive aphasia (PPA), a condition that slowly destroys language abilities. Using AI and real-time brain readings, the device customizes electrical stimulation to each person's unique brain pa…

This study looks at whether racism-related stress makes it harder for Black adults with insomnia to benefit from cognitive behavioral therapy (CBTi). About 100 Black adults aged 18-65 with insomnia and depressive symptoms will use a digital CBTi program for 6 weeks. Researchers w…

This study tests a program called COORDINATE for older adults (50+) with two or more chronic conditions who are leaving a hospital step-down unit. A nurse helps participants set goals, track symptoms, and ask better questions to their care team. The goal is to see if this support…

This study tests whether a handheld robot that vibrates and talks can help older adults with mild memory problems sleep better. 100 participants will either use the robot or a standard meditation app for several weeks. The goal is to see if the robot's touch and breathing cues ma…

This study tests a device called Scrambler Therapy to see if it can safely reduce nerve pain in children with cancer that has spread to the bone. About 70 children will receive the non-invasive treatment, and researchers will measure changes in pain intensity and medication use. …

This study will test if a biofeedback breathing system called Freespira can reduce anxiety and panic symptoms in 73 children and teens aged 9 to 17. Participants must have a diagnosed anxiety disorder and a high score on a standard anxiety screening test. The main goal is to see …

This early-stage trial will test whether a form of lithium called lithium orotate is safe, tolerable, and reaches the brain in 40 adults with early Alzheimer's disease. Participants will take the supplement or a placebo daily for 9 weeks, and researchers will measure side effects…

This study tests whether a gentle, noninvasive brain stimulation technique called tDCS, combined with thinking exercises, can improve memory and attention in people who had a traumatic brain injury at least two years ago. About 20 adults will receive personalized brain stimulatio…

This study tests whether simple changes to the bedroom environment and basic sleep tips can improve sleep in older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to make agreed-upon adjustmen…

This pilot study tests whether N-acetylcysteine (NAC), an antioxidant supplement, can reduce repetitive and self-injurious behaviors in people with Cornelia de Lange Syndrome (CdLS). Ten participants aged 13 to 35 will receive either NAC or a placebo for 8 weeks, then switch afte…

This study will compare custom 3D printed splints made at the hospital with those made by an outside company for jaw surgery. The splints help surgeons align the teeth and jaws correctly during the operation. Researchers want to see if the in-house splints are faster to get, chea…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention in people who use cannabis often versus rarely. Researchers will give 40 healthy adults either a placebo, a low dose, or a high dose of THC and test their eye con…

This pilot study tests whether a pre-visit questionnaire helps Black parents of preterm infants with chronic lung disease set and achieve care goals. About 30 parents will fill out the questionnaire before a well-child visit and complete follow-up surveys. The goal is to see if t…

This study looks at whether a leaky blood-brain barrier and immune changes cause thinking and mood problems in people with ME/CFS (chronic fatigue syndrome). Researchers will compare people who got ME/CFS before the COVID-19 pandemic with those who developed it after. They will u…

This early-stage study will look at how vaporized beta-myrcene (a compound found in cannabis and other plants) and THC affect healthy adults who use cannabis. Researchers want to understand how these substances interact in the body and what effects they produce. The study involve…

This study tests a web-based app called Health-E You/Salud iTu that teen boys use before doctor visits to help them discuss sexual and reproductive health. About 2,752 males aged 13-21 who have had sex will use the app, and researchers will measure if it improves condom use and r…

This study looks at how cannabis products labeled as indica, sativa, or generic affect people's thinking, driving, and feelings. About 70 healthy adults aged 21-55 will take part. Researchers will measure memory, attention, driving skills, and how people feel after using cannabis…

This early-phase study tests a new radioactive tracer called [11C]CPPC for PET scans in 20 people with ALS and healthy volunteers. The goal is to see if the tracer can safely detect brain inflammation linked to ALS and track changes over time. This research aims to improve unders…

This early-stage study will give psilocybin to 18 healthy adults while also blocking a specific serotonin receptor (5-HT1a) to see how it changes the drug's effects. Researchers will measure mystical-type experiences and brain activity using surveys and EEG. The goal is to unders…

This study looks at how the optic nerve changes when eye pressure is lowered in people who do not have glaucoma. Researchers will take pictures of the optic nerve before and after using a daily glaucoma eye drop for two weeks. The goal is to compare these results with those from …

This study looks at whether a home-based exercise program (resistance training and stationary cycling) can protect or improve vision in people with glaucoma, a disease that damages eye nerves. Researchers will measure changes in vision, eye blood flow, and quality of life in 150 …