Can a salt substitute safely lower blood pressure? new study investigates

NCT ID NCT07460882

Not yet recruiting Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This study will test whether a low-sodium salt substitute, which contains potassium chloride, is safe for adults with high blood pressure who are on medication. About 607 participants in Bangladesh will replace regular salt with the substitute for a period. Researchers will monitor potassium levels in the blood to see if dangerous increases occur, and also check if it helps correct low potassium levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-sodium salt substitute (potassium chloride)
What this could lead to: If it works, this could show that low-sodium salt substitutes are safe for widespread use in people with high blood pressure, helping control blood pressure without major risks.
What could go wrong: This is an early pre-post study, not a randomized trial, so results may not be conclusive. There is a risk of high potassium levels (hyperkalemia), especially in people on certain blood pressure medications.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION

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