Brain leak clue to chronic fatigue and long COVID brain fog?
NCT ID NCT07256795
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Johns Hopkins study looks at whether a leaky blood-brain barrier and immune changes contribute to cognitive problems in people with ME/CFS (chronic fatigue syndrome), both those who got sick before the pandemic and those who developed it after COVID-19. Researchers will use brain scans and blood tests in 200 adults aged 18-70. The goal is to better understand the biology behind brain fog and memory issues in these conditions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could reveal why many people with ME/CFS or long COVID experience brain fog and memory problems, pointing toward new ways to diagnose or treat these cognitive issues.
What could go wrong
This is an observational study, not a treatment trial. It aims to understand the disease, not test a therapy. Results may not lead directly to new treatments, and findings might not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Johns Hopkins Hospital
Baltimore, Maryland, 21297, United States