Could pressurized oxygen ease chronic fatigue? new trial aims to find out

NCT ID NCT07621068

Not yet recruiting Symptom relief Sponsor: Assaf-Harofeh Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with mild to moderate chronic fatigue syndrome. 74 participants will receive either real treatment or a sham (placebo) for 60 sessions over 3 months. Researchers will measure physical performance, fatigue, and other symptoms to see if the therapy provides real relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber)
What this could lead to: If it works, this could offer a new way to reduce fatigue and improve daily function for people with chronic fatigue syndrome.
What could go wrong: This is an early-stage trial with only 74 participants, and the sham control may reveal no benefit. The treatment is time-intensive (60 sessions) and may not work for everyone.

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Conditions

The condition(s) this trial relates to.

myalgic encephalomeyelitis/chronic fatigue syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC FATIGUE SYNDROME

Contacts and locations

Locations

The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh)

Zrifin, 70300, Israel

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