Nurse support boosts TB treatment in south africa

NCT ID NCT02129244

Ongoing Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether having a nurse case manager helps people with multidrug-resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 patients in South Africa are involved. Half of the clinics have a nurse case manager to guide care, while the other half follow standard procedures. Researchers will compare treatment success rates between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nurse case management
What this could lead to: If successful, this approach could improve cure rates for drug-resistant TB, especially in patients also living with HIV.
What could go wrong: This is an observational study comparing existing care models, not testing a new drug. Results may vary by location and patient adherence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease multidrug-resistant tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV MDR-TB

Contacts and locations

Locations

Catherine Booth Hospital

aMatikulu, KwaZulu-Natal, South Africa
Don McKenzie

Durban, South Africa
Doris Goodwin Hospital

Pietermaritzburg, South Africa
Dunstan Farrell Hospital

Hibberdene, South Africa
Fort Gray Hospital

East London, South Africa
Fosa Hospital

Newlands West, South Africa
Hlabisa Hospital

Hlabisa, South Africa
Jose Pearson Hospital

Port Elizabeth, South Africa
King George V Hospital

Durban, South Africa
Manguzi

Manguzi, South Africa
Marjorie Parrish Hospital

Port Alfred, South Africa
Murchison Hospital

Port Shepstone, South Africa
Nkqubela

Mdantsane, South Africa
Regus Primary Office

Westville, Durban, 3629, South Africa
St Margaret's MDR-TB Hopsital

Umzimkulu, South Africa

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