Antioxidant pill may preserve sight in inherited eye disease
NCT ID NCT05537220
First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 29 times
Summary
This phase 3 trial tests whether an oral antioxidant called N-acetylcysteine (NAC) can slow the loss of vision in people with retinitis pigmentosa, an inherited eye disease that causes night blindness and tunnel vision. About 485 adults aged 18 to 65 will take NAC or a placebo daily for several years. The study measures changes in the retina's light-sensitive cells to see if NAC can protect remaining vision.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Emory University, Emory Eye Center
Atlanta, Georgia, 30322, United States
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Harvard University, Mass. Eye and Ear
Boston, Massachusetts, 02114, United States
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Mayo Clinic, Department of Ophthalmology
Rochester, Minnesota, 55905, United States
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McGill University, The Research Institute of the McGill University Health Center
Montreal, Quebec, H4A 3J1, Canada
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Medical College of Wisconsin, The Eye Institute
Milwaukee, Wisconsin, 53226, United States
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Medical University of Graz, Department of Ophthalmology
Graz, Styria, 8036, Austria
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Northwestern University
Evanston, Illinois, 60208, United States
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Radboud University, Radboud University Medical Centre
Nijmegen, Gelderland, 6500 HB, Netherlands
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Retina Foundation of the Southwest
Dallas, Texas, 75231, United States
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Scheie Eye Institute
Philadelphia, Pennsylvania, 19104, United States
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Stanford University, Byers Eye Institute
Stanford, California, 94303, United States
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University College London, Moorfields Eye Hospital
London, England, United Kingdom
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University Of Illinois At Chicago
Chicago, Illinois, 60612, United States
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University of Amsterdam, Amsterdam Medical Center
Amsterdam, Northern Holland, 1105 AZ, Netherlands
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University of California - Davis, Department of Ophthalmology & Vision Science
Davis, California, 95817, United States
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University of California - San Francisco, Department of Ophthalmology
San Francisco, California, 94158, United States
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University of Florida - Jacksonville, UF Health Jacksonville
Jacksonville, Florida, 32209, United States
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University of Iowa, Carver College of Medicine
Iowa City, Iowa, 52242, United States
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University of Miami, Bascom Palmer Eye Institute
Miami, Florida, 33136, United States
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University of Michigan, Kellogg Eye Center
Ann Arbor, Michigan, 48105, United States
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University of Minnesota, Department of Ophthalmology and Visual Neurosciences
Minneapolis, Minnesota, 55455, United States
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University of Oklahoma, Dean McGee Eye Institute
Oklahoma City, Oklahoma, 73104, United States
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University of Southern California, Keck School of Medicine
Los Angeles, California, 90089, United States
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University of Tübingen, Department für Augenheilkunde
Tübingen, Baden-Wurttemberg, 72076, Germany
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University of Utah, Moran Eye Center
Salt Lake City, Utah, 84132, United States
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University of Washington, Department of Ophthalmology
Seattle, Washington, 98109, United States
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University of Wisconsin - Madison, McPherson Eye Research Institute
Madison, Wisconsin, 53705, United States
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Universitätsspital Basel, Eye Clinic
Basel, CH-4031, Switzerland
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Vanderbilt University, Vanderbilt Eye Institute
Nashville, Tennessee, 37211, United States
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Vitreo Retinal Associates
Gainesville, Florida, 32607, United States
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Wilmer Eye Institute- Johns Hopkins University
Baltimore, Maryland, 21287, United States
Conditions
Explore the condition pages connected to this study.