Blood test for PMDD on the horizon? johns hopkins launches biomarker study

NCT ID NCT06771583

First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 33 times

Summary

This study from Johns Hopkins aims to find epigenetic markers in blood that could help identify premenstrual dysphoric disorder (PMDD). Researchers will collect blood samples and track mood changes across the menstrual cycle in 500 women — some with PMDD and some without. The goal is to see if certain DNA markers differ between the groups, which could lead to better diagnosis and understanding of the condition.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Johns Hopkins Reproductive Mental Health Center

    RECRUITING

    Baltimore, Maryland, 21205, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this study could point toward a biological test to diagnose PMDD and predict who might respond to certain treatments.

What could go wrong

This is an early observational study, not a treatment trial. The biomarkers may not reliably distinguish PMDD from controls, and results may not lead to a clinical test.

Conditions

The condition(s) this trial relates to.

Premenstrual Dysphoric Disorder premenstrual tension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.