Heart failure mystery: scientists probe energy failures in heart and muscles

NCT ID NCT03775577

Recruiting now Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why people with a type of heart failure (HFpEF) have trouble exercising. Researchers will measure energy use in the heart and leg muscles using special scans. They aim to link these energy problems to how well patients can walk and exercise. The study does not test any new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could reveal why people with heart failure struggle to exercise, pointing toward future therapies.
What could go wrong: This is an observational study, not a treatment trial. It may not lead directly to new therapies, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH NORMAL EJECTION FRACTION

Contacts and locations

Locations

Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States

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