New scan peers inside heart cells to spot early trouble

NCT ID NCT03549559

Recruiting now Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new imaging tracer called 11C-Martinostat that lights up a specific enzyme (histone deacetylase) in the heart during a PET-MRI scan. Researchers will compare enzyme activity in people with aortic stenosis or diabetes to healthy volunteers. The goal is to see if this scan can reveal early changes in heart muscle that might lead to better diagnosis of heart conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 11C-Martinostat (a radioactive imaging tracer)
What this could lead to: If successful, this could lead to a new way to detect early heart disease by imaging enzyme activity, potentially improving diagnosis and monitoring.
What could go wrong: This is an early imaging study, not a treatment trial. The tracer may not reliably distinguish between groups, and results may not translate to clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis diabetes mellitus diastolic heart failure Hypertrophy, Left Ventricular

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE STENOSIS DIABETES HEART FAILURE WITH NORMAL EJECTION FRACTION LEFT VENTRICULAR HYPERTROPHY

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

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