Johns hopkins tests which drugs really give a psychedelic trip
NCT ID NCT06772753
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study at Johns Hopkins University aims to see if various psychoactive substances—like ketamine, MDMA, and THC—produce experiences similar to classic psychedelics. Fifty healthy volunteers aged 25–55 will receive up to 6 different drugs or a placebo in blinded sessions. The main measure is a questionnaire about mystical-type experiences.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Psilocybin, Ketamine, Dextromethorphan (DXM), Dimethyltryptamine (DMT), Methylenedioxymethamphetamine (MDMA), Tetrahydrocannabinol (THC)
- What this could lead to
- If successful, this study could help identify which substances produce classic psychedelic experiences, potentially guiding future therapeutic use.
- What could go wrong
- This is an early Phase 1 study with only 50 healthy volunteers, so results may not apply to patients. The subjective nature of the outcomes also makes it hard to draw firm conclusions.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Johns Hopkins Center for Psychedelic and Consciousness Research
RECRUITINGBaltimore, Maryland, 21218, United States
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