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Could a common antidepressant help brain function in frontotemporal dementia?

NCT ID NCT06604520

Recruiting now Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the antidepressant vortioxetine can improve mood symptoms and thinking abilities in people with early-stage behavioral variant frontotemporal dementia (bvFTD). Participants will take the medication for 12 weeks and undergo brain scans and memory tests before and after treatment. The study aims to see if the drug leads to positive changes in brain activity and symptom relief.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

behavioral variant of frontotemporal dementia frontotemporal dementia Pick disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FRONTO-TEMPORAL DEMENTIA FRONTO-TEMPORAL LOBAR DEMENTIA FRONTOTEMPORAL DEGENERATION FRONTOTEMPORAL DEMENTIA FRONTOTEMPORAL DEMENTIA (FTD) FRONTOTEMPORAL DEMENTIA, BEHAVIORAL VARIANT

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The Johns Hopkins Hospital

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact