Can whole blood beat component transfusions in trauma?
NCT ID NCT05638581
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial asks whether giving severely injured patients whole blood (Low-Titer Group O) is better than giving them separate blood components (red cells, plasma, platelets, and cryoprecipitate) during emergency transfusions. It enrolls about 1,100 adults with major traumatic bleeding who need large-volume transfusions. The main goal is to see if whole blood improves survival within the first 6 hours after transfusion begins.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Low-Titer Group O Whole Blood (LTOWB) compared with standard blood components (red cells, plasma, platelets, cryoprecipitate)
- What this could lead to
- If whole blood proves better, it could become the standard emergency transfusion for trauma, potentially saving more lives in the critical first hours.
- What could go wrong
- The trial is large but results may not apply to all settings, and whole blood may not always be available or superior for every patient.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Atrium Health Wake Forest Baptist
NOT_YET_RECRUITINGWinston-Salem, North Carolina, 27157, United States
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Froedtert Hospital
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Harborview Medical Center
RECRUITINGSeattle, Washington, 98104, United States
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Los Angeles County + University of Southern California (LAC + USC) Medical Center
NOT_YET_RECRUITINGLos Angeles, California, 90033, United States
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Oregon Health and Sciences University Hospital
NOT_YET_RECRUITINGPortland, Oregon, 97239, United States
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Penn Presbyterian Medical Center
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University Medical Center New Orleans LCMC Health
NOT_YET_RECRUITINGNew Orleans, Louisiana, 70112, United States
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University of Alabama at Birmingham, UAB Hospital
RECRUITINGBirmingham, Alabama, 35294, United States
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University of Cincinnati Medical Center
RECRUITINGCincinnati, Ohio, 45267, United States
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University of Maryland Medical Center
NOT_YET_RECRUITINGBaltimore, Maryland, 21201, United States
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University of Texas Health San Antonio and University Health System
NOT_YET_RECRUITINGSan Antonio, Texas, 78229, United States
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University of Texas Health Science Center Houston
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
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Washington University School of Medicine
NOT_YET_RECRUITINGSt Louis, Missouri, 63110, United States
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