Tailored blood thinners could save limbs in PAD patients
NCT ID NCT07613840
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned to either the personalized plan or standard treatment. Their medications will be adjusted based on blood test results over a year to see if the tailored approach reduces clots, amputations, and repeat procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aspirin and Clopidogrel (blood thinners)
What this could lead to
If it works, this could lead to a more effective, personalized way to prevent blood clots and reduce amputations in people with peripheral artery disease after surgery.
What could go wrong
This is an early-stage trial with 484 participants, so results may not apply to everyone. The personalized plan may not reduce clots or could increase bleeding risks compared to standard care.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Salem Hospital (Mass General Brigham)
RECRUITINGSalem, Massachusetts, 01970, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••