Surgical trick could let amputees 'Feel' their missing limb again

NCT ID NCT04063592

Recruiting now Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 4 times

Summary

This study tests a new surgical procedure for people who have had a leg amputated. The surgery builds special connections between muscles to help the brain better control the remaining limb and restore a sense of position and movement. Researchers will enroll 26 adults who already have a below- or above-knee amputation and are experiencing pain or skin problems. The goal is to improve how well they can use a prosthetic and reduce muscle shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: residual limb revision surgery (agonist-antagonist myoneural interface construction)
What this could lead to: If successful, this surgery could give amputees better control over their prosthetic limb, restore a sense of where the limb is in space, and reduce muscle wasting.
What could go wrong: This is a small, early-stage study with only 26 people. Surgery carries risks like infection, poor wound healing, or need for additional operations. It may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPUTATION

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Massachusetts Institute of Technology
RECRUITING

Cambridge, Massachusetts, 02139, United States
Walter Reed National Military Medical Center
NOT_YET_RECRUITING

Bethesda, Maryland, 20889, United States

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