AMPUTATION

This study tested whether a special vacuum dressing (negative pressure wound therapy) helps wounds heal better after major leg amputations. 158 adults who had a leg amputation (not due to injury) took part. The goal was to see if this dressing reduces problems like infection, reo…

This study tested a new way of coordinating care for rural patients with diabetic foot ulcers, who are at higher risk of major leg amputation. The model connects rural clinics with specialists to ensure patients receive timely, guideline-based treatment. Researchers compared outc…

This study tested whether adding the antibiotic rifampin to standard treatment helps prevent amputations in diabetic patients with foot bone infections. Over 800 veterans participated, receiving either rifampin or a placebo for six weeks. The goal was to see if rifampin improves …

This study tested a new type of prosthetic leg for people who have lost a leg below or above the knee. The smart leg uses sensors to detect muscle signals and provides gentle vibrations to help the user feel the leg's position. It also has powered knee and ankle joints that activ…

This completed trial tested a new surgical procedure called an agonist-antagonist myoneural interface (AMI) in 14 people with below-knee amputations. The surgery connects muscle pairs in the residual limb to allow better communication with a bionic prosthetic. The goal was to imp…

This study tested a new way to perform leg amputations that connects muscles in the residual limb to act as biological motors. The goal is to allow people to control advanced prosthetic legs more naturally and with better feeling. Fifty adults needing a leg amputation due to inju…

This study tested whether injecting donor stem cells into the leg muscles before amputation could prevent wound problems and reduce the need for more amputations. 81 people scheduled for leg amputation due to poor blood flow took part. The main goal was to check safety, not yet t…

This pilot study tested hand and forearm transplants in 7 people who lost both hands. The goal was to see if the brain can adapt to the new hands and improve daily life. Participants had to be between 20 and 40 years old and have had their amputation 3 months to 3 years before th…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested a vacuum dressing called PREVENA on 272 adults who had a leg amputated. The dressing applies gentle suction over the surgical cut to help it heal and prevent complications like infection, reopening, or fluid buildup. The goal was to see if this device reduces wo…

This study looked at whether a 12-week core muscle training program could help teenage swimmers with limb amputations improve their trunk endurance and 50-meter freestyle time. Thirty swimmers were split into two groups: one did core training plus their usual swim practice, the o…

This study tested whether a new prosthetic foot called the Pro-Flex Pivot helps people with below-knee amputations move better than a standard energy-storing foot. Thirty adults who already use a standard foot wore each type for four weeks and reported their mobility and comfort.…

This completed study tested a new body-powered prosthetic hook designed to improve grasping for people with upper limb loss. Eight adults between 18 and 80 years old compared the new hook to standard hooks with different spring tensions. Researchers measured how fast participants…

This study tested a new hybrid pump that creates a vacuum to hold prosthetic limbs in place. Twelve people with leg amputations walked in a lab to see if the pump improved comfort and mobility. The goal was to verify the pump works during walking.

This study tested a new microprocessor-controlled prosthetic knee called NAVii in 14 people with leg amputations. Participants tried the new knee and then their usual knee, and researchers compared how satisfied they were walking downstairs and how far they could walk in six minu…

This study tested a motorized, computer-controlled knee (Mobili Knee) in 6 people who had a leg amputation above the knee and used a prosthetic. Participants performed walking and balance tests with their usual knee and with the powered knee. The goal was to see if the powered kn…

This study tested whether a medicated cloth (glycopyrronium) could reduce excessive sweating at the amputation site in 13 limb amputees. Participants used either the active cloth or a placebo for four weeks, then switched after a washout period. The goal was to see if less sweati…

This study tested a new digital system for creating prosthetic sockets while the person is standing (weight-bearing). The goal was to see if this method leads to a better fit, more comfort, and improved skin health compared to traditional non-weight-bearing methods. Ten adults wi…

This study compared adjustable prosthetic sockets to conventional ones in 29 people with leg amputations. Participants tried different sockets and reported comfort, mobility, and quality of life. The goal was to see if adjustable sockets offer benefits over standard ones.

This study tested a new powered prosthetic knee called Power Knee in 17 people with above-knee amputations. The goal was to see if it reduces effort during walking compared to their usual microprocessor knee. Participants walked for 6 minutes and rated their exertion. The study a…

This study tested a new type of prosthetic foot designed for people with below-knee amputation who have longer residual limbs. The foot is low-profile but built to be both flexible and strong. Six participants walked with the new foot and their usual prescribed foot so researcher…

This study tested a new microprocessor-controlled prosthetic knee (Navii Knee) in 11 people with above-knee amputations. Participants used the new knee for 4 weeks at home, and researchers measured satisfaction with stair and ramp descent, walking, balance, and overall quality of…

This study tested a new prosthetic foot for children with leg amputations or birth defects. Thirteen kids walked with the device and gave feedback on stiffness and performance. The goal was to gather ideas to improve future foot designs.

This study surveyed 128 adults in Gaza who have used a lower limb prosthesis for at least six months. Researchers measured their satisfaction with life and their prosthesis, as well as their overall quality of life during the ongoing war. No treatments or interventions were given…

This study tested different prosthetic feet in 13 people with below-knee amputations to see which one helps them walk best while carrying infants, toddlers, or other loads. Participants tried a standard foot, a foot with a heel-stiffening wedge, and a stiffer foot. The goal was t…

This study looked at 26 adults—some with a lower-leg amputation and some without—to see how amputation affects core muscle function, endurance, balance, and walking. Participants performed simple tests like reproducing knee angles and balancing. The goal is to understand these re…

This study tested whether prosthetists—specialists who fit artificial limbs—can screen for common but often unnoticed health problems like depression, nerve damage, and poor blood flow in people who have had a leg amputation. Seventy participants were split into two groups: one r…

This study looked at how powered ankle prostheses change the pressure inside the prosthetic socket and the health of the residual limb in people with below-knee amputations. Six adults who already use a standard prosthetic leg walked on level ground with different types of prosth…

This study investigated why humans swing their arms during walking, a common but poorly understood movement. Researchers had 25 participants, including healthy individuals and those with conditions like stroke or Parkinson's disease, walk on a force-sensing treadmill. They measur…

This study looked at how people with below- or above-knee amputations use their muscles and adjust their balance when the ground moves unexpectedly. Researchers measured muscle activity and recorded movements in 29 participants. The goal was to better understand balance strategie…

This completed study tested whether a low-cost prosthetic foot works as well as traditional ones for people with a below-knee amputation. Six participants performed balance, walking, and jumping tests with both types of feet. The goal was to see if the cheaper option could improv…