New dressing may keep amputation wounds clean and closed

NCT ID NCT03773575

Completed Prevention Sponsor: Thomas Jefferson University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a vacuum dressing called PREVENA on 272 adults who had a leg amputated. The dressing applies gentle suction over the surgical cut to help it heal and prevent complications like infection, reopening, or fluid buildup. The goal was to see if this device reduces wound problems and medical costs compared to standard bandages.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PREVENA™ PEEL & PLACE™ Dressing Kit (a vacuum dressing device)
What this could lead to: If it works, this could reduce wound complications like infection or reopening after leg amputation, potentially lowering hospital stays and repeat surgeries.
What could go wrong: This is a completed trial, but results may not apply to all patients or settings. The dressing is a device, not a drug, so benefits may be modest and depend on proper use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Seroma Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPUTATION AMPUTATION; POSTOPERATIVE, SEQUELAE LYMPH LEAKAGE SEROMA WOUND DEHISCENCE WOUND INFECTION, SURGICAL

Contacts and locations

Locations

Gemelli Hospital

Roma, RM, 8, 00168, Italy
Thomas Jefferson University/Hospital

Philadelphia, Pennsylvania, 19107, United States
Westchester Medical Center

Valhalla, New York, 10595, United States

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