Could your own skin cells make a prosthetic limb fit better?
NCT ID NCT04839497
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 33 times
Summary
This phase 2 trial is testing whether injecting a person's own skin cells into the residual limb can improve skin firmness for amputees who use a prosthetic. Twenty adults with a below-knee amputation will receive either the cell injection or a placebo. Researchers will monitor safety and measure changes in skin firmness over three months.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Johns Hopkins Hospital
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
autologous volar fibroblast injection
What this could lead to
If it works, this could offer a way to improve skin firmness and comfort for amputees using prosthetics.
What could go wrong
This is a small early-phase trial with only 20 participants, so results may not apply to everyone. Possible side effects include bruising, swelling, or infection at the injection site.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.