New surgery showdown: which technique best stops phantom limb pain?
NCT ID NCT06840262
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This pilot study tests two surgical methods—targeted muscle reinnervation (TMR) and regenerative peripheral nerve interfaces (RPNI)—alone and together to reduce chronic and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned to one of three groups. The goal is to see which approach is safest and most effective at easing pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
surgical procedures (targeted muscle reinnervation and regenerative peripheral nerve interfaces)
What this could lead to
If successful, this study could identify which surgical technique best reduces chronic and phantom limb pain after amputation in cancer patients, improving quality of life.
What could go wrong
This is a small pilot study with only 45 participants, so results may not apply to everyone. The techniques are surgical and carry risks like infection or nerve damage.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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