New surgery showdown: which technique best stops phantom limb pain?

NCT ID NCT06840262

Recruiting now Symptom relief Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This pilot study tests two surgical methods—targeted muscle reinnervation (TMR) and regenerative peripheral nerve interfaces (RPNI)—alone and together to reduce chronic and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned to one of three groups. The goal is to see which approach is safest and most effective at easing pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical procedures (targeted muscle reinnervation and regenerative peripheral nerve interfaces)
What this could lead to: If successful, this study could identify which surgical technique best reduces chronic and phantom limb pain after amputation in cancer patients, improving quality of life.
What could go wrong: This is a small pilot study with only 45 participants, so results may not apply to everyone. The techniques are surgical and carry risks like infection or nerve damage.

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Conditions

The condition(s) this trial relates to.

cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPUTATION

Contacts and locations

Locations

M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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Other studies related to the condition(s) this trial covers.