Limb ischemia

This study is testing a device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to see i…

This study is testing a device called the Indigo Aspiration System to remove blood clots from leg arteries in people with acute limb ischemia, a condition where a clot suddenly blocks blood flow. About 300 participants will undergo a procedure where the device sucks out the clot.…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people with severe leg artery disease (chronic limb-threatening ischemia) avoid amputation or death. About 200 adults who recently had a procedure to restore leg blood flow will take either colc…

This pilot study tests whether giving special nutritional shakes before and after surgery can improve the health of patients with critical limb ischemia, a severe form of peripheral artery disease. About 30 participants will drink the shakes for one to two weeks before and after …

This study tests whether taking two blood thinners (aspirin and clopidogrel) for 12 months after leg artery surgery is better than taking them for just 1 month in people with severe leg artery disease. The goal is to see if longer treatment prevents amputations or death. About 61…

This study compares a paclitaxel-coated balloon to a standard balloon for opening blocked arteries below the knee in people with chronic limb-threatening ischemia, a serious condition that can lead to amputation. About 288 participants will be randomly assigned to one of the two …

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study tests a special balloon coated with medicine (SELUTION SLR™ 014) to open blocked arteries below the knee in people with severe leg pain or wounds that threaten the limb. About 376 adults with chronic limb-threatening ischemia will be randomly assigned to get either the…

This study is testing a device called the LimFlow Stent Graft System for people with late-stage chronic limb-threatening ischemia, a severe form of peripheral artery disease where blood flow to the leg is critically low. The device creates a new connection between a vein and arte…

This study tests a new drug called APAC, which is designed to prevent blood clots in people with blocked leg arteries. The trial includes 42 adults with peripheral arterial disease or chronic limb-threatening ischemia. Researchers will check if APAC is safe and well-tolerated, an…

This study is tracking 1,000 people with severe leg artery disease (chronic limb-threatening ischemia) who are getting a drug-coated balloon to open blocked arteries below the knee. The balloon releases a drug (paclitaxel) to help keep the artery open. Researchers want to see if …

This study tests a procedure that connects an artery to a vein in the foot to bring blood to tissues when standard treatments have failed. It includes 50 patients with severe leg artery disease and active wounds. The goal is to see if the procedure is safe and can prevent major a…

This early-stage study tests a new tube (cannula) placed in the leg artery during heart surgery that uses a heart-lung machine. The device is designed to keep blood flowing to the leg, reducing the risk of limb damage. Fifteen adults having planned heart surgery will be enrolled,…

This study tests a new type of stent that slowly dissolves and releases medication to keep leg arteries open. It is for people with chronic limb-threatening ischemia, a serious condition where blocked arteries can lead to amputation. About 300 participants will be randomly assign…

This study tests whether a laser device called the Auryon Atherectomy System, used with standard balloon angioplasty, works better than balloon angioplasty alone for people with severe leg artery blockages (critical limb ischemia). The trial will enroll 224 adults who are at risk…

This study compares two methods for opening blocked arteries in the lower leg in people with chronic limb-threatening ischemia, a severe condition that can lead to amputation. One group gets standard balloon angioplasty guided by X-ray images (angiography). The other group uses a…

This study tests a drug called Fortelyzin, which is injected directly into blood clots to dissolve them, in people with acute limb ischemia (sudden loss of blood flow to a limb). The goal is to see if it can prevent amputation as well as or better than standard surgery. About 170…

This study is tracking 500 people who had a procedure using the Pounce Thrombectomy System, a device that removes blood clots from arteries in the legs without open surgery. The goal is to see how well the device restores blood flow and how safe it is. The study is retrospective,…

This study tests whether injecting donor stem cells (Stempeucel) into the leg muscle can help people with critical limb ischemia, a severe form of peripheral artery disease. Ten Malaysian patients who cannot have surgery or angioplasty will receive the stem cells and be followed …

This study is testing whether injections of Stempeucel, a stem cell product made from donor bone marrow, can help people with critical limb ischemia caused by Buerger's disease. The goal is to see if it reduces pain, heals ulcers, improves blood flow, and prevents amputation. Onl…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tests whether music therapy delivered by the BeatMove device can help people with leg artery disease walk farther during a 3-month outpatient walking program. Fifty-four participants will either get real music therapy or a sham version while doing 36 walking sessions. …

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study explores whether a thermal imaging camera can detect changes in blood flow to the legs after a procedure to reopen blocked arteries. Researchers will compare temperature readings from the camera with standard ankle-brachial index measurements in 25 people with severe p…

This study tests a new device called the Spur scaffold, used with a drug-coated balloon, to treat blocked arteries below the knee in people with chronic limb-threatening ischemia (CLTI). The study includes 40 high-risk patients—those with diabetes or on dialysis—and measures how …

This study tracks 98 people with peripheral artery disease who had a stent placed in their iliac artery. Researchers want to see which patients later develop serious limb complications, like needing another procedure or amputation. They will also check if frailty plays a role. Th…

This study is testing whether a quick ultrasound measurement of blood flow in the foot (called systolic rise time) can predict major limb events like amputation or severe ischemia in people with critical limb ischemia. Researchers will follow 134 patients for 6 months after surge…

This study looks at whether giving extra oxygen through a mask (normobaric oxygen therapy) can help people with critical limb ischemia, a severe lack of blood flow to the legs that can lead to amputation. Researchers will compare the health and treatments of 200 patients who do o…

This study tests whether a new type of PET/MR scan using a tracer called FAZA can measure oxygen levels in leg tissues of people with critical limb ischemia, a severe form of peripheral artery disease. About 40 adults who are scheduled for a procedure to restore blood flow will g…

This study tests whether non-invasive sensors can detect reduced blood flow in the legs during long pelvic surgeries. Thirty adults will be monitored during their procedure. The goal is to see if this approach can help prevent complications like limb ischemia.

This study looks at immune cells called macrophages in the arteries of people with heart disease or poor leg circulation. Researchers will use imaging and blood tests to see how these cells are activated. The goal is to better understand the disease, not to test a new treatment. …

This study follows 100 stroke survivors with arm weakness to see how their own sense of arm use changes during intensive rehab. Researchers compare patients' perceptions with actual arm function using standard tests. The goal is to better understand the gap between what patients …

This observational study aims to better understand what happens inside artery plaques in people with peripheral artery disease (PAD). Researchers will use special PET-CT scans to look for signs of inflammation, calcium buildup, and blood clots in the legs and other parts of the b…

This study compares two techniques for guiding a needle into a blocked leg artery from the opposite direction (retrograde). One uses a live X-ray map, the other uses ultrasound. Researchers want to see which is safer and more successful in 32 people with severe leg artery disease…

This study tests a new device that continuously measures pressure in the leg to detect a dangerous condition called compartment syndrome in patients on ECMO. ECMO patients are often sedated and cannot report symptoms, making diagnosis difficult. The device may help doctors diagno…

This study compares standard 2D X-ray imaging with a 3D imaging technique called OCT during leg artery procedures. About 166 adults with blocked leg arteries will be randomly assigned to one of two groups. The goal is to see if OCT helps doctors place stents and inflate balloons …

This study looks at whether using special tools to measure blood flow and take ultrasound images during leg bypass surgery can help predict how well the graft will work over time. It involves 450 people with severe leg artery disease who are having a vein bypass below the knee. T…