New drug could save limbs without surgery
NCT ID NCT05372718
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a drug called Fortelyzin, which is injected directly into blood clots to dissolve them, in people with acute limb ischemia (sudden loss of blood flow to a limb). The goal is to see if it can prevent amputation as well as or better than standard surgery. About 170 adults with moderate to severe limb ischemia will be randomly assigned to receive the drug or undergo surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Fortelyzin (recombinant non-immunogenic staphylokinase)
What this could lead to
If successful, this could offer a non-surgical option to restore blood flow and prevent limb amputation in people with acute limb ischemia.
What could go wrong
This is still being tested in 170 people, so results may not apply to everyone. The drug could cause bleeding or fail to dissolve the clot, requiring surgery anyway.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Kaliningrad Regional Clinical Hospital
RECRUITINGKaliningrad, 236016, Russia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Kazan City Hospital No. 7
RECRUITINGKazan', 420103, Russia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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Kursk city emergency hospital
RECRUITINGKursk, Kursl Region, 305035, Russia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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S.P. Botkin Moscow Multidisciplinary Scientific and Clinical Center
RECRUITINGMoscow, 125284, Russia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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S.S. Yudin City clinical hospital
RECRUITINGMoscow, 115446, Russia
Contact
Contact
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Sergiyev Posad Regional Clinical Hospital
RECRUITINGSergiyev Posad, Moscow Oblast, 141301, Russia
Contact Phone: •••-•••-••••
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Ufa Emergency City Hospital
RECRUITINGUfa, 450092, Russia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Volgograd City Clinical Hospital of Emergency #25
RECRUITINGVolgograd, 400138, Russia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact