Vein bypass offers hope for leg amputation patients

NCT ID NCT03807661

Completed Disease control Sponsor: LimFlow SA Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new procedure called percutaneous deep vein arterialization for people with critical limb ischemia, a severe form of leg artery disease. The procedure uses a device to create a bypass using a vein, aiming to improve blood flow and prevent amputation. The study included 28 people who had no other treatment options and measured how many survived without losing a limb.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LimFlow System (a device to create a vein bypass)
What this could lead to: If it works, this could offer a new way to save limbs and improve blood flow in people with severe leg artery disease who have no other options.
What could go wrong: This was a small, early study with only 28 people, so results may not apply to everyone. The procedure carries risks like infection, bleeding, or the bypass failing over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CRITICAL LIMB ISCHEMIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Chronic Limb-Threatening Ischemia limb ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL LIMB ISCHEMIA

Contacts and locations

Locations

Glenfield Hospital

Leicester, LE3 9QP, United Kingdom
Guy's and St Thomas' NHS Foundation Trust

London, SE1 9RT, United Kingdom
Manchester University NHS Foundation Trust

Manchester, M13 9WL, United Kingdom
North Bristol NHS Trust

Bristol, BS10 5NB, United Kingdom
Royal Liverpool and Broadgreen University Hospitals NHS Trust

Liverpool, L7 8XP, United Kingdom
St George's University Hospitals NHS Foundation Trust

London, SW17 0RE, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.