Simple foot tests could prevent thousands of diabetes amputations

NCT ID NCT05009602

Completed Diagnosis Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested several simple bedside tests—like ankle and toe blood pressure measurements and handheld Dopplers—to see how well they detect poor leg circulation (peripheral arterial disease) in 604 people with diabetes. The results were compared to advanced imaging scans (CTA or MRA). The goal is to find the most accurate and cost-effective way to diagnose circulation problems early and prevent leg amputations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could identify the most accurate and cost-effective bedside test for detecting poor leg circulation in people with diabetes, potentially reducing amputations.
What could go wrong: This is a completed diagnostic accuracy study, not a treatment trial. The results may not change clinical practice if no test proves clearly superior or cost-effective.

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Conditions

The condition(s) this trial relates to.

Chronic Limb-Threatening Ischemia diabetes mellitus Diabetic Foot limb ischemia peripheral arterial disease peripheral vascular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL LIMB ISCHEMIA CRITICAL LOWER LIMB ISCHEMIA DIABETIC FOOT DIABETIC FOOT ULCER PERIPHERAL ARTERIAL DISEASE PERIPHERAL ARTERY DISEASE PERIPHERAL VASCULAR DISEASES

Contacts and locations

Locations

Cardiff and Vale UHB

Cardiff, CF14 4XW, United Kingdom
Central London Community Healthcare NHS Trust sites

London, NW1 5JD, United Kingdom
Chelsea and Westminster Hospital NHS Foundation Trust

London, SW10 9NH, United Kingdom
Hammersmith and Fulham Partnership

London, United Kingdom
Hull University Teaching Hospitals NHS Trust

Hull, HU3 2JZ, United Kingdom
Imperial College Healthcare NHS Trust

London, W6 8RF, United Kingdom
Mid and South Essex NHS Foundation Trust

Basildon, SS16 5NL, United Kingdom
NHS Greater Glasgow and Clyde

Glasgow, G12 0XH, United Kingdom
Nottingham University Hospitals (NUH) NHS Trust

Nottingham, NG5 1PB, United Kingdom
Oxford University Hospitals NHS Foundation Trust

Oxford, OX4 2PG, United Kingdom
South Tees Hospitals NHS Foundation Trust

Middlesbrough, TS4 3BW, United Kingdom
St George's University Hospitals NHS Foundation Trust

London, SW17 0QT, United Kingdom
University Hospitals Plymouth NHS Trust

Plymouth, PL6 8DH, United Kingdom
University Hospitals Southampton NHS Foundation Trust

Southampton, SO16 6YD, United Kingdom
University Hospitals of Derby and Burton NHS Foundation Trust

Derby, DE22 3NE, United Kingdom
University Hospitals of Leicester NHS Trust

Leicester, LE1 5WW, United Kingdom
Worcestershire Acute Hospitals NHS Trust

Worcester, WR5 1DD, United Kingdom

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