Can a cheap arthritis pill save limbs and hearts?

NCT ID NCT04774159

Recruiting now Disease control Sponsor: Population Health Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a daily low dose of colchicine, an anti-inflammatory drug, can prevent heart attacks, strokes, and severe leg complications in people with peripheral artery disease (PAD). About 6,150 participants with symptomatic PAD will receive either colchicine or a placebo for several years. The goal is to see if reducing inflammation lowers the risk of major vascular events.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Colchicine (0.5 mg tablet daily)
What this could lead to: If it works, this could provide a new, affordable way to lower the risk of heart attacks, strokes, and severe leg problems in people with peripheral artery disease.
What could go wrong: This is a large Phase 3 trial, but colchicine may not reduce these risks as hoped. Side effects like stomach upset or rare serious reactions are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation inflammatory disease myocardial infarction peripheral arterial disease stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROSIS OF EXTREMITIES INFLAMMATION PERIPHERAL ARTERIAL DISEASE

Contacts and locations

Locations

AMCOR
RECRUITING

Quito, Ecuador
Bradford Teaching Hospital
RECRUITING

Bradford, United Kingdom
CIUSSS du Nord-de-l'île-de-Montréal, Hôpital du Sacré-Cœur-de-Montréal
RECRUITING

Montreal, Quebec, Canada
CPTEM - Centro de Pesquisa e Tecnologia Multidisciplinar
RECRUITING

São Paulo, Brazil
Cambridge University Hospitals
RECRUITING

Cambridge, United Kingdom
Cardiolife
RECRUITING

Quito, Pichincha, Ecuador
Centre intégré de santé et de services sociaux du Bas-Saint-Laurent
RECRUITING

Rimouski, Quebec, G5L 3N2, Canada
Clínica Procárdio
RECRUITING

Blumenau, Santa Catarina, Brazil
Corcare Cardiovascular Research Inc.
RECRUITING

Scarborough Village, Ontario, Canada
Derriford Hospital
RECRUITING

Plymouth, England, United Kingdom
Deventer Hospital
RECRUITING

Deventer, Netherlands
Duke Raleigh Hospital
RECRUITING

Raleigh, North Carolina, 27609, United States
Duke Regional Hospital
RECRUITING

Durham, North Carolina, 27704, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Glenfield Hospital
RECRUITING

Leicester, United Kingdom
HFR Fribourg
RECRUITING

Fribourg, Switzerland
Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Hospital Alemão Oswaldo Cruz
RECRUITING

São Paulo, Brazil
Hospital Carlos Fernando Malzoni
RECRUITING

Matão, Brazil
Hospital Universitário (CoraCentro Pesquisa Clinica)
RECRUITING

Canoas, Brazil
Hospital de Especialidades de las Fuerzas Armadas N 1
RECRUITING

Quito, Pichincha, Ecuador
Hull Royal Infirmary
RECRUITING

Hull, United Kingdom
Hôpitaux Universitaires de Genève
RECRUITING

Geneva, Switzerland
Incore
RECRUITING

Dois Vizinhos, Brazil
Instituto de Cardiologia do Rio Grande do Sul
RECRUITING

Porto Alegre, Brazil
Kent and Canterbury Hospital
RECRUITING

Canterbury, England, United Kingdom
London Health Sciences Centre
RECRUITING

London, Ontario, Canada
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Niagara Health System
RECRUITING

St. Catharines, Ontario, Canada
Norfolk and Norwich University Hospitals
RECRUITING

Norwich, United Kingdom
Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
Ospedale Regionale Bellinzona e Valli - Ente Ospedaliero Cantonale
RECRUITING

Bellinzona, Switzerland
Pinderfields Hospital
RECRUITING

Wakefield, England, United Kingdom
Royal Infirmary Edinburgh
RECRUITING

Edinburgh, Scotland, United Kingdom
Royal Sussex County Hospital
RECRUITING

Brighton, England, United Kingdom
Rutgers University
RECRUITING

Newark, New Jersey, 07103, United States
Santa Casa de Misericórdia de Ponta Grossa
RECRUITING

Ponta Grossa, Brazil
Sentara Norfolk General Hospital
RECRUITING

Norfolk, Virginia, 23507, United States
Sir Charles Gairdner Hospital
RECRUITING

Perth, Western Australia, Australia
Slingeland Hospital
RECRUITING

Doetinchem, Netherlands
Sociedade Hospitalar Angelina Caron
RECRUITING

Campina Grande do Sul, Brazil
Southmead Hospital
RECRUITING

Bristol, England, United Kingdom
Southwest Family Medicine
RECRUITING

Dallas, Texas, 75235, United States
St. George's University Hospitals
RECRUITING

London, United Kingdom
St. Thomas Hospital
RECRUITING

London, United Kingdom
Sunnybrook Research Institute
RECRUITING

Toronto, Ontario, Canada
Tampa General Hospital
RECRUITING

Tampa, Florida, 33606, United States
Texas Tech University Health Sciences
RECRUITING

Lubbock, Texas, 79430, United States
The Leeds Teaching Hospital
RECRUITING

Leeds, United Kingdom
Toronto General Hospital
RECRUITING

Toronto, Ontario, Canada
UniCarMeDr.D
RECRUITING

Quito, Pichincha, Ecuador
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, Belgium
University Hospital Basel, Angiology
RECRUITING

Basel, Switzerland
University Hospital Southampton
RECRUITING

Southampton, United Kingdom
University Hospital Zurich, Clinic of Angiology
RECRUITING

Zurich, Switzerland
University Medical Center Groningen
RECRUITING

Groningen, Netherlands
University Medical Center Utrecht
RECRUITING

Utrecht, Netherlands
University of Alberta, Mazankowski Heart Institute
RECRUITING

Edmonton, Alberta, Canada
University of Calgary, Peter Lougheed Centre Vascular Clinic
RECRUITING

Calgary, Alberta, Canada
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60615, United States
University of Florida - Gainesville
RECRUITING

Gainesville, Florida, 32611, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Vascular Health Bronte
RECRUITING

Oakville, Ontario, Canada
Via Medica
RECRUITING

Goiânia, Brazil
Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06511, United States

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