Population Health Research Institute

This study compares two types of blood thinners (DOAC vs VKA) in people who have had open-heart surgery and also have atrial fibrillation, a heart rhythm problem. The goal is to see which one causes less major bleeding in the first 30 days after surgery. About 3500 adults will ta…

This study tests whether a low dose of colchicine, an anti-inflammatory drug, can reduce the risk of serious heart problems and limb complications in people with peripheral artery disease (PAD). About 6,150 adults with symptomatic PAD will take either colchicine or a placebo dail…

This study looks at whether taking blood thinners can prevent strokes in people who have brief episodes of atrial fibrillation (irregular heartbeat) triggered by stress, such as after surgery or a serious illness. About 2,270 participants with additional stroke risk factors will …

This study compares bariatric surgery to standard medical weight management in 200 adults with severe obesity (BMI 30 or higher) and high-risk cardiovascular disease. The goal is to see if surgery reduces major heart problems like heart attacks, strokes, and heart failure hospita…

This study tests whether a widely used antibiotic, azithromycin, can reduce deaths in adults with advanced HIV. About 8,000 participants will receive either the antibiotic or a placebo. The goal is to see if this simple, low-cost approach can save lives in the first 24 weeks of t…

This study is for adults who have a mechanical heart valve in the aortic position and must take warfarin for life. It tests whether a lower INR target (1.5 to 2.5) can reduce serious bleeding without increasing the risk of blood clots or stroke. About 2,625 participants will be f…

This study looks at whether doing hip fracture surgery sooner (within hours) can lower the chance of death within 90 days for patients who also have a recent heart injury. About 1100 adults aged 45 and older with a hip fracture and elevated troponin (a sign of heart damage) will …

This study aims to see if a simple heart test can diagnose Calcium Release Deficiency Syndrome (CRDS), a rare genetic condition that increases the risk of sudden cardiac death. Researchers will compare heart rhythm changes in people with CRDS, those with a similar condition (CPVT…

This study creates a global registry for people with Calcium Release Deficiency Syndrome (CRDS), a rare genetic heart condition that can cause dangerous heart rhythms. Researchers will collect data from 500 participants to better understand the condition's symptoms, risks, and be…