Population Health Research Institute

This study is testing whether bariatric surgery (like gastric bypass) can safely reduce the risk of major heart problems—such as heart attacks, strokes, and heart failure—in people with severe obesity and high heart risk. About 700 participants will be randomly assigned to either…

This study tests whether a short course of amiodarone can reduce the return and burden of atrial fibrillation (AF) in 400 adults who develop new AF after heart surgery. Participants receive either standard care or amiodarone for 4 weeks. The goal is to see if this approach is pra…

This study tests whether a daily low dose of colchicine, an anti-inflammatory drug, can prevent heart attacks, strokes, and severe leg complications in people with peripheral artery disease (PAD). About 6,150 participants with symptomatic PAD will receive either colchicine or a p…

This study tests whether blood thinners (NOACs) can prevent stroke in people who develop atrial fibrillation only during stressful events like surgery or serious illness. About 2,270 participants will be randomly assigned to take a blood thinner or not, and researchers will track…

This study tests whether a lower target for blood thinning (INR 1.5 to 2.5) can reduce bleeding in people with a mechanical heart valve in the aortic position, without raising the risk of dangerous clots. About 2,625 participants who have had their valve for at least 3 months wil…

This study looks at whether doing hip fracture surgery within 6 hours, instead of waiting longer, can reduce deaths in patients who also have a recent heart injury. About 1100 adults aged 45 and older with a hip fracture and elevated troponin (a sign of heart damage) will be rand…

This study compares newer blood thinners (DOACs) to the standard drug warfarin in patients who need anticoagulation after open-heart surgery. About 3500 adults with atrial fibrillation will be randomly assigned to receive either a DOAC or warfarin for 30 days. The main goal is to…

This study tests whether taking the antibiotic azithromycin can reduce deaths in adults with advanced HIV. Researchers will give either azithromycin or a placebo to 8,000 participants and track who dies over 24 weeks. The goal is to see if this simple, cheap drug can save lives i…

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare inherited heart condition that increases the risk of sudden cardiac arrest. Researchers will use a pacing procedure to measure heart wave changes in 400 participants, inc…

This study is creating a worldwide registry for people with Calcium Release Deficiency Syndrome (CRDS), a rare genetic heart condition that can cause dangerous heart rhythms. Researchers will collect health information from 500 participants to better understand the condition's sy…