Population Health Research Institute

This study aims to find out which type of blood thinner is safer for patients in the first month after heart surgery when they need protection from strokes due to atrial fibrillation. It will compare newer direct oral anticoagulants (DOACs) with the older standard, vitamin K anta…

This international study is testing whether performing hip fracture surgery faster than usual improves survival and recovery for patients who also have signs of recent heart injury. It will compare accelerated surgery to standard care in 1,100 patients aged 45 and older. The main…

This large international trial is testing whether a 28-day course of the antibiotic azithromycin can reduce deaths in adults with very advanced HIV. It will enroll 8,000 participants with severely weakened immune systems and follow them for nearly a year. The goal is to see if th…

This study is testing whether weight loss surgery is better than medication and lifestyle changes at preventing serious heart problems in people who are severely obese and already have heart disease. Researchers will compare the rates of heart attacks, strokes, and heart-related …

This large, late-stage trial is testing whether a low daily dose of an existing anti-inflammatory drug (colchicine) can prevent serious complications in people with symptomatic peripheral artery disease (PAD). It aims to see if the drug reduces the combined risk of heart attacks,…

This study aims to find the safest dose of the blood thinner warfarin for people with mechanical heart valves. It will test if aiming for a lower blood-thinning level reduces serious bleeding while still preventing dangerous blood clots and strokes. The trial involves over 2,600 …

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare genetic heart condition that increases the risk of sudden cardiac death. Currently, diagnosing CRDS requires complex lab tests that are not widely available. Researchers …

This large international study aims to find out if taking blood-thinning medication is better than no treatment for preventing strokes in people who recently had a temporary, stress-related irregular heartbeat (atrial fibrillation) and have other risk factors for stroke. It will …

This study is creating a global registry to learn about a rare, newly discovered genetic heart condition called Calcium Release Deficiency Syndrome (CRDS). It aims to enroll 500 people who carry specific genetic changes to better understand the range of symptoms, identify risks, …