Can bariatric surgery save hearts? major trial aims to find out

NCT ID NCT05531474

Recruiting now Disease control Sponsor: Population Health Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether bariatric surgery (like gastric bypass) can safely reduce the risk of major heart problems—such as heart attacks, strokes, and heart failure—in people with severe obesity and high heart risk. About 700 participants will be randomly assigned to either surgery or standard medical weight management. The trial also looks at effects on mental health, thinking skills, and cost-effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bariatric surgery (gastric bypass, sleeve gastrectomy, or duodenal switch)
What this could lead to: If it works, this could show that bariatric surgery is a safe and effective way to lower the chance of major heart problems in people with severe obesity and existing heart disease.
What could go wrong: This is a large, ongoing trial, but surgery carries risks like infection or complications. Results may not apply to everyone, and the benefit over medical weight management is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder morbid obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARIATRIC SURGERY CANDIDATE CARDIOVASCULAR COMPLICATION

Contacts and locations

Locations

Hamilton Health Sciences
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada

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