Antibiotic trial aims to cut deaths in advanced HIV

NCT ID NCT05580666

Recruiting now Disease control Sponsor: Population Health Research Institute Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 22 times

Summary

This study tests whether a widely used antibiotic, azithromycin, can reduce deaths in adults with advanced HIV. About 8,000 participants will receive either the antibiotic or a placebo. The goal is to see if this simple, low-cost approach can save lives in the first 24 weeks of treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Phone: •••-•••-•••• Email: •••••@•••••

Locations

34 Military Hospital
RECRUITING

Freetown, Sierra Leone

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Adama Hospital Medical College
RECRUITING

Ādama, Ethiopia

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Africa Health Research Institute (AHRI)- Hluhluwe Clinic
NOT_YET_RECRUITING

Hluhluwe, South Africa

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Africa Health Research Institute (AHRI)- KwaMsane Clinic
NOT_YET_RECRUITING

Mtubatuba, South Africa

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Africa Health Research Institute (AHRI)- Mpukunyoni Clinic
NOT_YET_RECRUITING

Mtubatuba, South Africa

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Africa Health Research Institute (AHRI)- Mtubatuba Clinic
NOT_YET_RECRUITING

Mtubatuba, South Africa

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Africa Health Research Institute (AHRI)- Nkundusi Clinic
NOT_YET_RECRUITING

Hlabisa, South Africa

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Africa Health Research Institute (AHRI)- Somkhele Clinic
NOT_YET_RECRUITING

Mtubatuba, South Africa

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Aminu Kano Teaching Hospital
NOT_YET_RECRUITING

Kano, Nigeria

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Asella Referral and Teaching Hospital
RECRUITING

Āsela, Ethiopia

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Centre Hospitalier Universitaire de Kigali (CHUK)
NOT_YET_RECRUITING

Kigali, Rwanda

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Centre Intégré de Recherches Biocliniques d'Abidjan (CIRBA)
NOT_YET_RECRUITING

Abidjan, Côte d’Ivoire

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Centre médical de suivi des donneurs de sang (CMSDS)
NOT_YET_RECRUITING

Abidjan, Côte d’Ivoire

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College of Medicine and Allied Health Sciences, University of Sierra Leone
RECRUITING

Freetown, Sierra Leone

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Desmond Tutu Health Foundation
NOT_YET_RECRUITING

Cape Town, South Africa

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Faculty of Medicine, Eduardo Mondlane University
NOT_YET_RECRUITING

Maputo, Mozambique

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Federal Medical Center
NOT_YET_RECRUITING

Umuahia, Nigeria

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Groote Schuur Hospital -New main building, Infectious Disease Clinic G26
NOT_YET_RECRUITING

Cape Town, South Africa

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Jimma University Hospital
RECRUITING

Jimma, Ethiopia

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Jos University Teaching Hospital
ACTIVE_NOT_RECRUITING

Jos, Nigeria
Kenema Regional Hospital
RECRUITING

Kenema, Sierra Leone

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Koidu Government Hospital
RECRUITING

Koidu, Sierra Leone

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Komfo Anokye Teaching Hospital
NOT_YET_RECRUITING

Kumasi, Ghana

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Kumasi South Hospital
RECRUITING

Kumasi, Ghana

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Lagos University Teaching Hospital
RECRUITING

Lago, Nigeria

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Lilongwe Medical Relief Fund/UNC Project
NOT_YET_RECRUITING

Lilongwe, Malawi

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Livingstone hospital
RECRUITING

Port Elizabeth, South Africa

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MUJHU
RECRUITING

Kampala, Uganda

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Makeni Regional Hospital
RECRUITING

Makeni, Sierra Leone

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Mbarara Regional Referral hospital
RECRUITING

Mbarara, Uganda

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New Somerset Hospital
RECRUITING

Cape Town, South Africa

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Niger Delta University Teaching Hospital
NOT_YET_RECRUITING

Yenagoa, Nigeria

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Right to Care NPC, Esizayo Division
COMPLETED

Randburg, South Africa
SICRA Kampala
RECRUITING

Kampala, Uganda

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SICRA Lira
RECRUITING

Lira, Uganda

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Steve Biko Academic Hospital, University of Pretoria
RECRUITING

Pretoria, South Africa

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Suntreso Government Hospital
RECRUITING

Kumasi, Ghana

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The Aurum Institute
NOT_YET_RECRUITING

Klerksdorp, South Africa

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The Aurum Institute
NOT_YET_RECRUITING

Rustenburg, South Africa

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The Center for Infectious Disease Research in Zambia (CIDRZ)- George Clinical Research Site
NOT_YET_RECRUITING

Lusaka, Zambia

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The Center for Infectious Disease Research in Zambia (CIDRZ)- Matero Clinical Research Site
NOT_YET_RECRUITING

Lusaka, Zambia

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The Center for Infectious Disease Research in Zambia (CIDRZ)-Chawama Clinical Research Site (CRS)
NOT_YET_RECRUITING

Lusaka, Zambia

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Tigray health research institute (THRI)
NOT_YET_RECRUITING

Mek'ele, Ethiopia

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Ubuntu Clinic, Site B, Khayelitsha, Wellcome Centre
RECRUITING

Cape Town, South Africa

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Unité de Soins Ambulatoires et de conseils (USAC)
NOT_YET_RECRUITING

Abidjan, Côte d’Ivoire

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University College Hospital
RECRUITING

Ibadan, Nigeria

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University of Abuja Teaching Hospital
NOT_YET_RECRUITING

Abuja, Nigeria

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University of Calabar Teaching Hospital
NOT_YET_RECRUITING

Calabar, Nigeria

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University of Nigeria Teaching Hospital
RECRUITING

Enugu, Nigeria

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University of Uyo Teaching Hospital
ACTIVE_NOT_RECRUITING

Uyo, Nigeria
Usmanu Danfodiyo University Teaching Hos
ACTIVE_NOT_RECRUITING

Sokoto, Nigeria
Wits Health Consortium (Pty) Ltd
RECRUITING

Johannesburg, South Africa

Contact

Conditions

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HIV DISEASE PROGRESSION