New blood thinners may be safer after heart surgery
NCT ID NCT04284839
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares newer blood thinners (DOACs) to the standard drug warfarin in patients who need anticoagulation after open-heart surgery. About 3500 adults with atrial fibrillation will be randomly assigned to receive either a DOAC or warfarin for 30 days. The main goal is to see which approach causes fewer major bleeding events.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Direct oral anticoagulants (DOACs) such as apixaban, dabigatran, edoxaban, or rivaroxaban, compared to warfarin
What this could lead to
If DOACs prove safer, patients may have fewer major bleeding events after heart surgery while still preventing strokes.
What could go wrong
This is an early-phase trial with 3500 participants; results may not apply to all patients, and bleeding risks remain a concern.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hamilton General Hospital
RECRUITINGHamilton, Ontario, L8L 2X2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Health Science Centre
RECRUITINGSt. John's, Newfoundland and Labrador, A1B 3V6, Canada
Contact
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Health Sciences North Research Institute
RECRUITINGGreater Sudbury, Ontario, P3E 5J1, Canada
Contact
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Heart Center Leipzig
ACTIVE_NOT_RECRUITINGLeipzig, Saxony, 04289, Germany
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Hôpital Sacré-Coeur de Montréal
ACTIVE_NOT_RECRUITINGMontreal, Quebec, H4J1C5, Canada
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IUCPQ-ULaval
RECRUITINGQuébec, Quebec, G1V 4G5, Canada
Contact
Contact
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Montreal Heart Institute
RECRUITINGMontreal, Quebec, H1T 1C8, Canada
Contact
Contact
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Royal Melbourne Hospital, University of Melbourne
NOT_YET_RECRUITINGParkville, Victoria, 3050, Australia
Contact
Contact
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Saint John Regional Hospital
ACTIVE_NOT_RECRUITINGSaint John, New Brunswick, E2L4L2, Canada
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St Vincent's Hospital Melbourne
RECRUITINGFitzroy, Victoria, 3065, Australia
Contact
Contact
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St. Boniface Hospital
RECRUITINGWinnipeg, Manitoba, R2H 2A6, Canada
Contact
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Sunnybrook Hospital
RECRUITINGToronto, Ontario, M4N 3M5, Canada
Contact
Contact
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Toronto General Hospital
RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact
Contact
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University Hospital Bonn Heart Center
ACTIVE_NOT_RECRUITINGBonn, 53127, Germany
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University Hospital Jena
RECRUITINGJena, Thuringia, Germany, Germany
Contact
Contact
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University Medical Center Hamburg-Eppendorf
RECRUITINGHamburg, 20246, Germany
Contact
Contact
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University of Alberta Hospital
RECRUITINGEdmonton, Alberta, T6G 2C8, Canada
Contact
Contact
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University of British Columbia
RECRUITINGVancouver, British Columbia, V6T 1Z3, Canada
Contact
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West-German Heart and Vascular Center, University of Duisburg-Essen
NOT_YET_RECRUITINGEssen, 45147, Germany
Contact
Contact