New heart test could predict sudden cardiac death risk

NCT ID NCT06188689

Recruiting now Diagnosis Sponsor: Population Health Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare inherited heart condition that increases the risk of sudden cardiac arrest. Researchers will use a pacing procedure to measure heart wave changes in 400 participants, including those with CRDS and similar conditions. The goal is to replace current lab-based genetic testing with a simpler, faster diagnostic method.

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Conditions

The condition(s) this trial relates to.

Arrhythmias, Cardiac cardiac arrest catecholaminergic polymorphic ventricular tachycardia combined immunodeficiency due to CRAC channel dysfunction Death, Sudden, Cardiac

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CALCIUM RELEASE DEFICIENCY SYNDROME (CRDS)

Contacts and locations

Locations

Aarhus University Hospital
RECRUITING

Aarhus, DK-8200 N, Denmark
Alberta Health Services
RECRUITING

Edmonton, Alberta, T6G 2C8, Canada
Antwerp University Hospital
RECRUITING

Edegem, Antwerp, 2650, Belgium
Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CHU de Bordeaux
RECRUITING

Bordeaux, New Aquitaine, 33404, France
Children's & Women's Health Centre of British Columbia
RECRUITING

Vancouver, British Columbia, V6H 3N1, Canada
Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval
RECRUITING

Québec, Quebec, G1V 4G5, Canada
London Health Sciences Centre - University Hospital
RECRUITING

London, Ontario, N6A 5A5, Canada
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Montréal Heart Institute
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
Ottawa Heart Institute
RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada
Oxford University Hospitals
RECRUITING

Oxford, Oxfordshire, OX3 9DU, United Kingdom
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
The University of British Columbia
RECRUITING

Vancouver, British Columbia, V6T 1Z3, Canada
Toronto General Hospital
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Universitair Ziekenhuis Brussel
RECRUITING

Brussels, 1090, Belgium
University of Calgary
RECRUITING

Calgary, Alberta, T2N 1N4, Canada
University of California
RECRUITING

San Francisco, California, 94143, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States

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