Sound waves could spot hidden artery disease without needles or radiation
NCT ID NCT06952543
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study at Mayo Clinic is testing a new, non-invasive ultrasound technique to detect peripheral arterial disease (PAD) earlier and more easily. Researchers will compare the ultrasound results with standard tests like ankle-brachial index and CT scans. The study includes 400 people with PAD symptoms and healthy volunteers, aiming to see if this method can also track disease changes after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ultrasound imaging with Angio Flow Reactivity Analysis (AFRA)
- What this could lead to
- If successful, this could provide a simple, non-invasive way to diagnose peripheral artery disease earlier and track how well treatments are working.
- What could go wrong
- This is an early-stage diagnostic study, not a treatment trial. The new ultrasound method may not prove more accurate than existing tests like the ankle-brachial index.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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