PERIPHERAL ARTERIAL DISEASE

This early study tested the safety and performance of a special balloon coated with the drug sirolimus. The balloon is used to open narrowed arteries in the leg (femoropopliteal arteries) in patients with peripheral artery disease. The goal was to see if the drug-coated balloon c…

This study tested a device called the LifeStream Stent Graft to treat severe blockages in the main arteries of the pelvis and leg (iliac arteries). It involved 70 patients with advanced peripheral artery disease to see if the device could keep the artery open and improve blood fl…

This study tested a two-step procedure for people with severely hardened and blocked leg arteries. First, a special shockwave device was used to crack the hard calcium deposits inside the artery. Then, a drug-coated mesh tube (stent) was placed to prop the artery open. The goal w…

This study tested a medical device called the Kaitoh Atherectomy System for treating blocked leg arteries in people with peripheral artery disease. The device physically removes plaque buildup to restore blood flow. Researchers followed 9 participants to check if the procedure wa…

This small study tested a new metal stent designed to open blocked arteries in the pelvis that supply blood to the legs. Doctors placed the stent through an artery in the wrist instead of the groin to see if it was safe and practical. The main goals were to check for complication…

This study tested whether a special educational program could help people with severe leg artery disease (critical limb ischemia) manage their condition better. 184 patients were randomly assigned to receive either the education program plus standard care or just standard care al…

This study tested a new, temporary stent device designed to open severely blocked arteries below the knee in patients with advanced peripheral artery disease. The goal was to improve blood flow to relieve pain, heal wounds, and prevent amputations. Researchers followed 130 patien…

This study observed 322 patients with severe, complete blockages inside previously placed leg artery stents. It aimed to see how well newer, minimally invasive procedures could keep these arteries open and prevent patients from needing repeat surgeries over two years. The researc…

This early-stage study tested whether injecting donor stem cells into the leg muscles of patients about to have a major amputation could help prevent serious wound complications after surgery. The main goal was to check if the injections were safe. Researchers also wanted to see …

This study tested if using video calls with specialists could get faster care for people in rural areas with serious foot sores from diabetes and poor blood flow. Researchers compared patients who had video consultations to those who had to travel for standard in-person visits. T…

This study tested a digital tool called KomPas+ designed to help physical therapists and their patients work together more effectively. The tool uses treatment guidelines to create personalized plans for people with leg pain caused by poor circulation (intermittent claudication).…

This study looked at whether patients who were hospitalized for serious heart or stroke events received the recommended cholesterol-lowering medications when they left the hospital. Researchers followed 129 patients to see if doctors prescribed drugs proven to significantly lower…

This study tested a new stent graft device designed to open long blockages in the main arteries of the leg. It involved 60 adults with peripheral artery disease who had leg pain from poor circulation. The main goals were to see if the device was safe and if it kept the artery ope…

This study tested a new medical tool called the AngioSafe System. It is designed to help doctors safely navigate through completely blocked arteries in the legs of people with severe peripheral artery disease. The main goal was to see if the device could successfully guide a wire…

This study aimed to find the best simple bedside test for detecting poor leg circulation (peripheral arterial disease) in people with diabetes. Researchers compared several quick tests, like blood pressure measurements in the ankle and toe, against more complex imaging scans. The…

This study tested if a special vacuum-sealed bandage (called Prevena) could prevent wound problems after leg artery surgery. It focused on patients at high risk for complications like infections or wounds reopening. Researchers compared the vacuum dressing to standard bandages to…

This study tested whether a simple deep breathing exercise could help patients feel better after a procedure to open blocked leg arteries. 100 patients were randomly assigned to either do the breathing exercises or receive standard care after their procedure. Researchers measured…

This study tested whether a daily leg stretching routine, with or without a creatine supplement, could help people with peripheral artery disease (PAD) walk farther and more comfortably. Researchers measured how far 13 participants could walk in six minutes and used special scans…

This study tested whether a weekly injectable diabetes medicine called semaglutide could help people with type 2 diabetes and leg artery disease walk farther with less pain. Nearly 800 participants were randomly assigned to receive either semaglutide or a placebo injection for ab…

This study tested whether a small, wearable pain relief device (TENS) and an education program could help people with leg pain from poor circulation (intermittent claudication) become more physically active. Researchers wanted to see if it was practical to run a larger future tri…

This study tested a special type of spring-powered footwear, called exoskeleton footwear, to see if it could help people with Peripheral Artery Disease (PAD) walk better. PAD causes painful leg cramps when walking. Researchers tested the shoes on 47 people over 40, including some…

This study tested whether adding body awareness therapy to standard physical therapy helps people with peripheral artery disease (PAD). Fifty-one adults with PAD were split into two groups: one received standard exercises, and the other received standard exercises plus body aware…

This study followed 797 patients with peripheral arterial disease (PAD) for one year to see how their leg pain, walking ability, and quality of life changed with different treatments. Researchers tracked patients' experiences to identify gaps in care and potential disparities bas…

This study tested a new imaging method to see if it could measure blood flow in the feet. Researchers compared scans from 34 healthy people and patients with diabetes and clogged leg arteries. The goal was to see if this scan could show how well a procedure to open blocked arteri…

This study looked for a link between gum health and a substance in the blood linked to heart disease risk. Researchers measured this substance in the blood and saliva of 61 people with clogged leg arteries. They compared levels between people with healthy gums, gum disease, or no…

This study aimed to understand how a tiny molecule in the body, called microRNA-210, is involved in the stress and energy problems that occur in the muscles of people with peripheral artery disease (PAD). Researchers compared 180 patients who had a procedure to improve blood flow…

This study aimed to understand how blood flow in the legs changes when people with poor leg circulation (peripheral artery disease) exercise their arms. Fifteen participants performed arm cycling, warm foot baths, or rested while researchers used ultrasound to measure blood flow …