PERIPHERAL ARTERIAL DISEASE

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This study tested a device called the PQ Bypass System in 78 people with severe peripheral artery disease (blocked leg arteries). The device is designed to create a bypass inside the artery using small tubes (stent grafts) placed through a needle puncture, avoiding the need for t…

This study tested whether a newer stent (Supera) works better than a standard stent for people with blocked arteries in the leg. About 300 patients received one of the two stents. The goal was to see which stent kept the artery open longer and reduced the need for another procedu…

This study tested a new device that uses sound waves to break up calcium deposits in leg arteries of people with peripheral artery disease. Thirty-five participants received the treatment to see if it was safe and could open blocked arteries. The goal was to improve blood flow wi…

This early study tested whether injections of cells from donated placentas are safe for people with blocked leg arteries and diabetic foot ulcers. Fifteen adults with diabetes received one of several doses. The main goal was to check for side effects and find the safest dose. Thi…

This study tested a temporary stent designed to open blocked arteries below the knee in people with peripheral artery disease or critical limb ischemia. The goal was to improve blood flow and prevent serious complications like amputation. The trial involved 130 participants and m…

This Phase 3 trial tested whether adding cilostazol to rosuvastatin helps people with peripheral artery disease (PAD) more than rosuvastatin alone. PAD narrows leg arteries, causing pain and trouble walking. The study enrolled 260 adults who took either the combo or a placebo for…

This study looked at how well the AURYON atherectomy device works for people with peripheral artery disease (PAD), where leg arteries become blocked. The device uses a laser to vaporize plaque and restore blood flow. Researchers followed 102 patients to see if the procedure was s…

This pilot study tested a hybrid rehabilitation program for people with peripheral arterial disease (PAD), a condition that causes leg pain and limits walking. The program combines a few on-site supervised sessions with a home-based walking plan to make it easier for patients to …

This completed study tested a two-step treatment for severely calcified leg artery disease in 50 patients. First, a shockwave device cracks the hard calcium deposits, then a drug-coated stent is placed to keep the artery open. The goal was to see if this approach is safe and effe…

This completed Phase 4 trial studied 60 people with peripheral artery disease (PAD) to see if adding low-dose rivaroxaban to aspirin improves blood vessel function and reduces clotting. Participants took either rivaroxaban plus aspirin or a placebo plus aspirin. The study measure…

This pilot study tested whether delivering the drug paclitaxel directly to the leg artery during angioplasty could reduce the chance of the artery narrowing again. 27 adults with leg pain from blocked arteries took part. The main goal was to see if the drug helped keep the artery…

This study looked at different treatments for people whose leg artery stents had become completely blocked. It included 322 adults with severe leg pain or wounds. The goal was to see how well the treatments restored blood flow and how long it lasted without needing another proced…

This completed study tested the LifeStream stent graft in 70 people with severe blockages in the iliac arteries (the main arteries in the pelvis). The device is a mesh tube that props open the artery and lines it to keep it clear. Researchers measured how well the artery stayed o…

This study tested a new tool called the AngioSafe Peripheral CTO Crossing System in 79 people with blocked leg arteries (peripheral artery disease). The goal was to see if the device could safely help doctors place a guidewire through the blockage. The study measured how often th…

This study tested whether a new stent (Dynetic-35) can safely open blocked arteries in the leg when inserted through the wrist instead of the groin. Twenty-five people with peripheral artery disease took part, and the main goal was to see if the procedure was safe and feasible. T…

This study tested a special balloon coated with sirolimus, a drug that helps keep arteries open, in 34 people with peripheral artery disease (narrowed leg arteries). The goal was to see if the balloon is safe and works well at improving blood flow and symptoms like leg pain. Part…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested a device called the PQ Bypass Stent Graft System in 60 people with peripheral artery disease who had long blockages in their leg arteries. The goal was to see if the device could safely open the artery and improve blood flow. Participants received the stent graf…

This study tested whether injecting donor stem cells into the leg muscles before amputation could prevent wound problems and reduce the need for more amputations. 81 people scheduled for leg amputation due to poor blood flow took part. The main goal was to check safety, not yet t…

This completed study tested a handheld device called the Kaitoh Atherectomy System in 9 people with peripheral artery disease (PAD). The device uses a rotating blade to shave away plaque buildup in leg arteries, aiming to restore blood flow. Researchers checked for safety and how…

This study tested several simple bedside tests—like ankle and toe blood pressure measurements and handheld Dopplers—to see how well they detect poor leg circulation (peripheral arterial disease) in 604 people with diabetes. The results were compared to advanced imaging scans (CTA…

This study tested a device called Prevena, a sterile sponge that applies gentle suction to a closed surgical wound for 5-7 days after groin surgery. The goal was to see if it lowers the chance of wound infections, reopening, or fluid leaks compared to a standard dry gauze dressin…

This study tested whether semaglutide, a diabetes medicine, improves walking ability in people with type 2 diabetes and peripheral artery disease (narrowed leg arteries). About 792 adults received weekly injections of semaglutide or a placebo for 59 weeks. The main goal was to se…

This study tested whether guided deep breathing exercises can reduce pain and improve vital signs in 100 patients who had a procedure to open blocked leg arteries (angioplasty). Half the patients did slow, deep belly breathing after surgery, while the other half received standard…

This completed study tested a 4-week educational program for 184 people with critical limb ischemia, a severe form of peripheral artery disease that can lead to amputation. The program included group sessions, digital materials, and peer support to teach patients about their cond…

This small Phase 2 trial tested whether taking creatine supplements combined with a muscle-stretching device could help people with peripheral artery disease (PAD) walk longer. Thirteen participants either received creatine plus stretching or a placebo (cellulose) plus stretching…

This study tested whether adding body awareness therapy—relaxation, breathing, and gentle movements—to standard physiotherapy helps people with peripheral artery disease (PAD). Fifty-one adults with PAD were split into two groups: one got standard exercises, the other added body …

This study tested whether wearing virtual reality (VR) glasses during a leg artery procedure (angioplasty) can lower patients' pain and anxiety. 52 adults having elective angioplasty were randomly assigned to either use VR or standard care. Researchers measured pain and anxiety l…

This study tested whether a digital app called KardioPAC could help people in cardiac rehab stay more active and feel better. 43 heart patients used the app alongside standard rehab, or just standard rehab alone. The goal was to see if the app improved exercise habits, blood pres…

This study tested special exoskeleton footwear designed to assist walking in people aged 40 and older with peripheral artery disease (PAD). Researchers compared different levels of assistance to see which worked best for comfort and walking performance. The study included 47 part…

This study tested whether a small device called TENS, which sends mild electrical pulses to the skin, could reduce leg pain during walking in people with peripheral artery disease (PAD). It also looked at adding a patient education program to encourage more physical activity. The…

This study tested whether screening high-risk patients for hidden peripheral arterial disease using a simple ankle blood pressure test is cost-effective. Over 600 patients were involved, and researchers compared different screening and counseling strategies. The goal was to see i…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study looked at whether measuring carbon dioxide in a patient's breath at rest (PETCO2) can help predict lung and heart complications after major vascular surgery. Researchers studied 91 older adults who were scheduled for aortobifemoral bypass surgery. The goal was to see i…

This study looked at 26 people with peripheral arterial disease (PAD) to see how arm exercise changes oxygen levels in their leg muscles. Participants used an arm ergometer while a sensor measured calf oxygen saturation. The goal was to understand why arm training can improve leg…

This completed study looked at 26,000 patients who had outpatient procedures for blood vessel problems like peripheral artery disease, varicose veins, or dialysis access issues. The goal was to see how safe and effective these procedures are when done in an office-based angiosuit…

This completed observational study looked at 61 people with peripheral artery disease to see if their gum health was linked to levels of a substance called TMAO in their blood and saliva. Researchers compared TMAO levels among those with healthy gums, gum disease, or no teeth. Th…

This study tested a special imaging method (SPECT/CT) to measure blood flow in the leg muscles of people with peripheral arterial disease (PAD) and diabetes. Researchers compared these images to those from healthy volunteers to see how treatment affects muscle blood flow. The goa…

This study looked at a molecule called microRNA-210 in 230 people with peripheral artery disease (PAD), a condition where leg arteries become blocked. Researchers measured its levels and linked them to oxidative stress and walking ability. The goal was to understand how this mole…

This study looks at how arm cranking exercise and warm water foot immersion change blood flow and shear stress in the leg arteries of people with peripheral artery disease (PAD). Fifteen participants with PAD and claudication symptoms will complete three sessions: arm exercise, w…

This study combines data from nearly 1,000 patients who received a special stent-graft (the GORE VIABAHN with a heparin coating) for peripheral artery disease in the leg. Researchers want to see how well the device keeps arteries open over time and which patient factors affect su…

This study tested a tool called KomPas+ that helps therapists and patients with leg pain from blocked arteries (intermittent claudication) make shared decisions about treatment. Over 2,200 participants used the tool to see if it improved walking distance and quality of life. The …

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study followed nearly 800 people with peripheral artery disease (PAD) for one year to see how different treatments affect their symptoms, daily function, and quality of life. Researchers measured health status using a special questionnaire and looked for differences based on…

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…