Laser catheter shows promise for unclogging leg arteries

NCT ID NCT04229563

Completed Disease control Sponsor: Angiodynamics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how well the AURYON atherectomy device works for people with peripheral artery disease (PAD), where leg arteries become blocked. The device uses a laser to vaporize plaque and restore blood flow. Researchers followed 102 patients to see if the procedure was safe and effective right after treatment and over time. The goal was to see if the device could clear blockages with few complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AURYON Atherectomy System (a laser catheter device)
What this could lead to: If successful, this device could offer a safe and effective way to clear blockages in leg arteries, improving blood flow and reducing symptoms like pain or wounds.
What could go wrong: This is a small, single-arm registry (102 people) with no comparison group, so results may not apply to everyone. Risks include vessel damage, blood clots, or need for further procedures.

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Conditions

The condition(s) this trial relates to.

Arterial Occlusive Diseases Bites and Stings Chronic Limb-Threatening Ischemia intermittent vascular claudication peripheral arterial disease peripheral vascular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFRAINGUINAL PERIPHERAL ARTERY DISEASE PAD PERIPHERAL ARTERIAL DISEASE

Contacts and locations

Locations

Amavita Clinical Research

Miami, Florida, 33169, United States
Comprehensive Cardiovascular

Davenport, Florida, 33837, United States
First Coast Cardiovascular Institute

Jacksonville, Florida, 32256, United States
Hurricane Cardiology

New Braunfels, Texas, 78130, United States
Medical City Heart and Spine

Dallas, Texas, 75243, United States
Midwest Cardio. research foundation

Davenport, Iowa, 52803, United States
NJ Endovascular Amputation Prevention

Clifton, New Jersey, 07013, United States
Pima Vascular

Tucson, Arizona, 85718, United States
Pulse Cardiovacular

Scottsdale, Arizona, 85259, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States

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