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When to transfuse? study tests best blood strategy for heart patients after surgery

NCT ID NCT03229941

Completed Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below 7). The goal was to see which approach better prevents complications like heart attack, kidney failure, stroke, or death within 90 days after surgery.

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Conditions

The condition(s) this trial relates to.

acute kidney injury ischemic stroke myocardial infarction myocardial ischemia peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RENAL FAILURE CORONARY REVASCULARIZATION MYOCARDIAL INFARCTION

Contacts and locations

Locations

  • Asheville VA Medical Center, Asheville, NC

    Asheville, North Carolina, 28805, United States

  • Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR

    Little Rock, Arkansas, 72205-5484, United States

  • James A. Haley Veterans' Hospital, Tampa, FL

    Tampa, Florida, 33612, United States

  • Louis Stokes VA Medical Center, Cleveland, OH

    Cleveland, Ohio, 44106, United States

  • Michael E. DeBakey VA Medical Center, Houston, TX

    Houston, Texas, 77030, United States

  • Minneapolis VA Health Care System, Minneapolis, MN

    Minneapolis, Minnesota, 55417, United States

  • North Florida/South Georgia Veterans Health System, Gainesville, FL

    Gainesville, Florida, 32608, United States

  • San Francisco VA Medical Center, San Francisco, CA

    San Francisco, California, 94121, United States

  • VA Loma Linda Healthcare System, Loma Linda, CA

    Loma Linda, California, 92357, United States

  • VA Long Beach Healthcare System, Long Beach, CA

    Long Beach, California, 90822, United States

  • VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX

    Dallas, Texas, 75216, United States

  • VA Palo Alto Health Care System, Palo Alto, CA

    Palo Alto, California, 94304-1290, United States

  • VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

    Pittsburgh, Pennsylvania, 15240, United States

  • VA Portland Health Care System, Portland, OR

    Portland, Oregon, 97239, United States

  • VA Puget Sound Health Care System Seattle Division, Seattle, WA

    Seattle, Washington, 98108, United States

  • VA Western New York Healthcare System, Buffalo, NY

    Buffalo, New York, 14215, United States

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