Creatine and stretching: a new hope for leg pain?
NCT ID NCT04471792
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small Phase 2 trial tested whether taking creatine supplements combined with a muscle-stretching device could help people with peripheral artery disease (PAD) walk longer. Thirteen participants either received creatine plus stretching or a placebo (cellulose) plus stretching for four weeks. The main goal was to see if walking distance improved in a six-minute walk test. The study also measured muscle oxygen levels using special imaging.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Creatine monohydrate
What this could lead to
If it works, this could point toward a simple, low-cost way to improve walking ability in people with peripheral artery disease.
What could go wrong
This is a very small, early-phase trial with only 13 participants. Results may not apply to everyone, and the benefits of creatine for this condition are not yet proven.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Florida State University
Tallahassee, Florida, 32304, United States