Creatine and stretching: a new hope for leg pain?

NCT ID NCT04471792

Completed Symptom relief Sponsor: Florida State University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small Phase 2 trial tested whether taking creatine supplements combined with a muscle-stretching device could help people with peripheral artery disease (PAD) walk longer. Thirteen participants either received creatine plus stretching or a placebo (cellulose) plus stretching for four weeks. The main goal was to see if walking distance improved in a six-minute walk test. The study also measured muscle oxygen levels using special imaging.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Creatine monohydrate
What this could lead to: If it works, this could point toward a simple, low-cost way to improve walking ability in people with peripheral artery disease.
What could go wrong: This is a very small, early-phase trial with only 13 participants. Results may not apply to everyone, and the benefits of creatine for this condition are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for PERIPHERAL ARTERIAL DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL ARTERIAL DISEASE

Contacts and locations

Locations

Florida State University

Tallahassee, Florida, 32304, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.