Could a simple supplement ease leg pain and help PAD patients walk farther?

NCT ID NCT06409949

Recruiting now Symptom relief Sponsor: University of Nebraska Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether taking MitoQ for six months can improve walking ability and quality of life in people with peripheral artery disease who experience leg pain while walking. Researchers will measure treadmill walking distance, daily step counts, and leg muscle health in 60 participants. Half will receive MitoQ and half a placebo, with results compared after six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MitoQ (a dietary supplement that targets mitochondria)
What this could lead to: If it works, this could point toward a simple supplement to help people with PAD walk farther and feel better day-to-day.
What could go wrong: This is an early-stage trial with only 60 people, so results may not apply widely. MitoQ is a supplement, not a proven drug, and may show no benefit over placebo.

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Conditions

The condition(s) this trial relates to.

peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL ARTERIAL DISEASE

Contacts and locations

Locations

VA Medical Center
RECRUITING

Omaha, Nebraska, 68105, United States

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