University Of Nebraska

This early-phase study tests whether tamoxifen, a drug commonly used for breast cancer, can shrink or stabilize pre-cancerous pancreatic cysts in women. The goal is to see if taking tamoxifen for up to 24 weeks can delay or eliminate the need for surgery. The study will enroll 15…

This study compares two ways to prevent brain tumors from growing back after surgery. One group gets a chemotherapy wafer (GLIADEL) placed directly where the tumor was removed, while the other group receives radiation treatment within six weeks. The trial aims to see if the wafer…

This study tests whether a prebiotic supplement called resistant starch can improve gut microbiome diversity in people with multiple myeloma or lymphoma after an autologous stem cell transplant. Thirty participants will take either the prebiotic or a placebo for about 10 days bef…

This study tests whether using a special PET scan (PSMA-PET) to guide radiation can reduce short-term side effects in men whose prostate cancer returns after surgery. About 54 men will receive targeted radiation to the pelvis plus a boost to spots seen on the scan, along with sta…

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a fast-growing brain tumor) has returned after standard treatment. The drugs are temozolomide (a chemotherapy pill given daily at low doses) and abexinostat (an experimental drug that may …

This study is for men with prostate cancer that has spread to pelvic lymph nodes only detectable by a special PSMA scan. It compares standard hormone therapy plus radiation to a stronger combination adding abiraterone and prednisone. The goal is to see if the stronger treatment i…

This study is for adults aged 60 and older with blood cancers who need a stem cell transplant. It compares a standard high dose of a drug (cyclophosphamide) with a lower dose, both combined with another drug (sirolimus), to prevent graft-versus-host disease (GVHD). The goal is to…

This study tests a new way to give radiation for prostate cancer that has not spread. It combines two types of radiation: one placed inside the prostate and another aimed at the prostate and nearby lymph nodes from outside the body. The goal is to control the cancer while keeping…

This study is testing whether a device that measures how long it takes for a pulse to travel through the arms and legs can detect peripheral artery disease (PAD), a condition where leg arteries become narrowed. Researchers will compare this new method to the standard ankle-brachi…

This study tests whether giving free colorectal cancer screening kits (FIT) to African Americans at a DMV office in Omaha can boost screening rates. 1,200 participants aged 45-75 will receive a kit, educational materials, and reminders. Half will also see social media ads. Resear…

This early-phase trial tests whether a single dose of Vumerity (diroximel fumarate) can improve blood vessel function and walking ability in 20 people aged 50-75 with peripheral artery disease (PAD). Participants will receive either Vumerity or a placebo, and researchers will mea…

This study tests a program where parents get support from trained parent coaches to help their teens quit vaping. About 200 parent-teen pairs will take part, with some receiving the program and others not. The main goal is to see if teens can stop vaping for at least 7 days.

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce opioid prescriptions and pain after breast conserving surgery. 260 breast cancer patients will be randomly assigned to receive either the ERAS protocol or standard care. The ERAS protocol inclu…

This study tests whether a daily nasal spray containing oxytocin, a natural hormone, can lower stress and improve quality of life in female family caregivers of people with dementia. About 32 women aged 50 and older who provide unpaid care will receive either a low or high dose o…

This study tests whether escitalopram, a common antidepressant, can improve thinking and memory problems in people with a severe type of brain tumor called grade IV glioma. Up to 85% of these patients struggle with cognitive issues from the tumor or its treatment. The study will …

This pilot study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in healthy adults and in older adults with amnestic mild cognitive impairment (aMCI), a condition that often leads to Alzheimer's. Researche…

This study tests a device called the Lung Master, which is meant to increase lung capacity by practicing slow, deep breaths. Twenty adults with or without breathing conditions will use the device daily at home for one month. Researchers will measure lung function before and after…

This study tests a mobile app called Family Room, designed to help family caregivers of ICU patients feel more engaged, satisfied, and less stressed. The app provides education, emotional support, and guidance on comfort care activities at the bedside. Researchers will compare ap…

This study tests whether taking MitoQ for six months can improve walking ability and quality of life in people with peripheral artery disease who experience leg pain while walking. Researchers will measure treadmill walking distance, daily step counts, and leg muscle health in 60…

This study looks at whether meeting with a coach, either in person or by video, helps adults with a certain type of heart failure (HFpEF) exercise more regularly. About 300 participants will be split into three groups for 18 months: one with no coach, one with in-person coaching,…

This study tests whether high-frequency spinal cord stimulation can reduce leg pain and improve quality of life in people with both peripheral arterial disease (PAD) and painful diabetic neuropathy. Fifteen adults who already have a spinal cord stimulator implanted will receive t…

This study tests whether at-home lower-body heat therapy can help older adults (ages 50-90) with long COVID improve their walking ability and overall physical function. Participants will use heat therapy at home, and researchers will measure changes in walking distance, physical …

This study tests a training program for caregivers of adolescents (ages 10-17) with profound autism. The training teaches caregivers how to use picture-based activity schedules to help their child complete tasks on their own. Researchers will see if the training is practical and …

This study looks at whether a tailored exercise program can help older blood cancer survivors slow down the aging process. Researchers will enroll 180 people aged 50 and older who have had blood cancer. The goal is to see if participants can stick with the exercise plan and if it…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study is looking for clues to predict how well different rheumatoid arthritis (RA) drugs will work in individual patients. Researchers will give 400 adults with RA one or more standard medications and track their response over 16 weeks. The goal is to find genetic or other f…

This study looks at whether small composite attachments on molars used with clear aligners increase gum inflammation in teenagers. Researchers will measure inflammatory markers in gum fluid from 30 teens, comparing those with and without attachments. The goal is to understand if …

This study looks at blood clotting in people with autoimmune skin diseases like bullous pemphigoid and lupus. Researchers will collect blood samples from 39 participants—some with active disease and some with mild or controlled disease—plus 15 healthy controls. They will measure …

This study looks at how deep brain stimulation (DBS) changes attention and the way people with Parkinson's disease, essential tremor, or dystonia perceive emotions in others' faces. Researchers will track eye movements and ask participants to rate facial expressions before, durin…

This study looks at whether six weeks of group therapy can change the gut microbiome in women experiencing chronic stress. Participants will fill out stress questionnaires and mail in stool samples before and after the therapy sessions. The goal is to understand the link between …

This pilot study looks at whether refractive surgeries like LASIK change the results of optical coherence tomography (OCT), a common eye scan used to monitor conditions like glaucoma. Researchers will measure the thickness of the retina and other eye layers before and after surge…

This study looks at whether giving ICU teams real-time feedback and extra nurse support helps them consistently use a set of proven care steps for patients on breathing machines. About 8,100 critically ill adults will take part across multiple ICUs. The goal is to find practical …

This study is following 1,250 people at higher risk for pancreas cancer, including those with new diabetes, pancreatic cysts, or a family history. Researchers will collect blood samples and health data twice a year for several years. The goal is to find early markers in the blood…

This study looks at how well the mouth heals after a tooth is pulled in younger and older adults. Half of the 12 participants will get a special blood product called platelet-rich fibrinogen placed in the extraction site. Researchers will compare healing and bone growth between t…

This study uses brain mapping techniques like fMRI and MEG before, during, and after surgery to see how brain functions like movement and speech reorganize in people with brain tumors. Researchers hope to improve surgical planning and preserve important brain functions. The study…

This study looks at how inflammation in the gums affects the body's immune response during wound healing after a tooth is pulled. Researchers will measure gum health before extraction, take small tissue samples right after and again two weeks later, and check healing at three mon…

This study tests a simple, passive leg movement called LEAP therapy in people with peripheral artery disease (PAD). Participants sit for 2.5 hours with or without the leg movement, and researchers measure blood flow, walking ability, and other health markers. The goal is to see i…

This study looks at how using a 3D-printed prosthetic hand changes brain activity in children born with missing fingers, hands, or arms. Researchers will use a brain imaging technique called fNIRS to measure brain responses while children perform tasks with the prosthesis. The go…