Brain tumor surgery may get a boost: chemo wafer could replace radiation
NCT ID NCT04222062
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways to prevent brain tumors from growing back after surgery. One group gets a chemotherapy wafer (GLIADEL) placed directly where the tumor was removed, while the other group receives radiation treatment within six weeks. The trial aims to see if the wafer works as well as radiation. About 100 adults with up to four brain metastases are being recruited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Carmustine wafer (GLIADEL)
- What this could lead to
- If it works, this could offer a one-time treatment option during surgery to reduce the chance of brain tumors returning, potentially avoiding the need for radiation.
- What could go wrong
- This is an early phase 2 trial with only 100 participants, so results are not yet proven. The wafer may not prevent recurrence as well as radiation, and there are risks from surgery and the chemotherapy itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
-
Contact
Email: •••••@•••••
Locations
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Henry Ford
NOT_YET_RECRUITINGDetroit, Michigan, 48202, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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