University Of Nebraska

This phase II trial studied 92 women with early-stage breast cancer to see how well chemotherapy (paclitaxel and cyclophosphamide) with or without trastuzumab works before surgery. The main goals were to check side effects and see if the tumor disappears completely by the time of…

This early-phase trial tested a drug called ONC-201 in 20 people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who had recently received a stem cell transplant. Participants took the drug by mouth once a week for a year to see if it was safe and co…

This study tested an oral drug called ADX-629 in 8 people with Sjögren-Larsson syndrome, a rare inherited disorder that causes harmful fatty substances to build up in the skin, brain, and eyes. The main goals were to see if the drug is safe and can reduce these fatty aldehydes. P…

This study looked at whether giving vitamin D supplements to people with low vitamin D levels and newly diagnosed non-Hodgkin lymphoma or chronic lymphocytic leukemia could improve their outcomes. About 197 participants received either a low or high dose of vitamin D while underg…

This phase II study tested a combination of two chemotherapy drugs (cyclophosphamide and paclitaxel) plus the targeted drug trastuzumab given after surgery to 20 patients with early-stage HER2-positive breast cancer. The goal was to see if this regimen is safe and can help preven…

This study tested whether matching chemotherapy intensity to a patient's genetic risk and overall health could improve outcomes for older adults (60+) with acute myeloid leukemia. 75 participants received either standard intensive or lower-intensity chemo based on their individua…

This study tested whether a visual biofeedback program during squats can improve knee loading and prevent osteoarthritis after ACL reconstruction. 34 participants were assigned to either standard physical therapy or standard therapy plus real-time visual feedback on a screen duri…

This study compared two collagen wound dressings—one from pigs and one from cows—placed in tooth extraction sites along with a bone graft. Nineteen non-smoking adults aged 19-65 who needed a premolar or front tooth pulled took part. Researchers measured soft tissue thickness and …

This early-phase study tested whether a drug called Leukine (sargramostim) is safe for people with Parkinson's disease when taken for 36 months. Seven participants received a weight-based dose 5 days a week. Researchers monitored side effects, immune system changes, and motor sym…

This study tested a program called PARITY that gives Black pregnant women a doula, community resources, and a mobile app with positive messages and wellness tips. The goal was to see if the program is practical and helpful for managing blood pressure and promoting healthy pregnan…

This study looked at whether a tiny drop of blood from a finger prick can be used to test for pregnancy, instead of drawing blood from a vein. Thirty women who were already known to be pregnant took part. The goal was to see if the finger-stick method gives accurate positive or n…

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method …

This study tested a breathing technique called Holotropic Breathwork to see if it helps people recover from addiction. 25 adults took part, either in a residential treatment program or living in the community. The goal was to see if the practice is safe, acceptable, and might red…

This small study tested a new way to treat microstomia (a tight, small mouth) caused by scleroderma. Three adults received three sessions of a laser treatment that delivered hyaluronidase, an enzyme that breaks down tight tissue, directly into the skin. The goal was to improve mo…

This study tested a low-cost, portable exercise program for people with non-small cell lung cancer after surgery. The goal was to help them manage severe fatigue and improve their quality of life. 235 adults took part, and the program was designed to be safe and practical for nea…

This study tested two approaches to help young adults (ages 19-29) stop vaping: media literacy education combined with text message support, and financial incentives. Forty participants who wanted to quit vaping in the next 30 days were enrolled. The study measured how many peopl…

This study tested whether a robotic baby harp seal could help children aged 5-18 feel less anxious and more motivated during physical or occupational therapy in the hospital. Twenty-five kids used the robot during their sessions, and researchers measured their pain, anxiety, and …

This study tested whether hyperbaric oxygen therapy — breathing pure oxygen in a pressurized chamber — could reduce pain and hospital stays for adults having a sickle cell pain crisis. Eight adults with uncomplicated crises received 1 to 3 sessions. Researchers measured pain chan…

This study tested a mobile app called BounceBack Now, designed to help people manage trauma-related mental health issues like PTSD, depression, and anxiety. Researchers worked with 29 adults in primary care, including many from underserved groups, to see if the app was easy to us…

This study looked at whether different doctors can consistently measure certain angles on pelvic X-rays. Thirty-three healthy adults had X-rays taken while sitting and standing. Four doctors then measured the same images to see if they agreed. The goal is to find out if these mea…

This study looked at whether virtual reality can help stroke survivors who have an uneven walk (one leg takes longer steps than the other). 42 adults who had a stroke at least 3 months ago took part. They learned a new walking task in virtual reality, and researchers measured how…

This study looked at whether a blood test can measure beta cell death in people with cystic fibrosis, which may help predict diabetes. About 40 participants with cystic fibrosis and healthy controls gave blood samples to check for a specific DNA marker. The goal was to understand…

This study looked at how stem cell transplants affect thinking, memory, and daily activities in adults aged 60 to 85 with blood cancer. Researchers measured cognitive function, physical function, and quality of life at several points after transplant. The goal was to understand w…

This study tested a simple, patient-chosen screening tool to help women of childbearing age identify health risks before pregnancy. About 286 women visiting family clinics for routine care used either a short or long screening form. The goal was to see if the tool could improve r…

This early-phase study tested the safety of a drug called sargramostim (Leukine) in 11 people with Parkinson's disease over 48 weeks. Researchers also looked for changes in immune cells and other biomarkers that might help track the disease. The goal was not to cure Parkinson's b…