New laser combo eases tight mouths in rare skin disease
NCT ID NCT05995626
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This small study tested a new way to treat microstomia (a tight, small mouth) caused by scleroderma. Three adults received three sessions of a laser treatment that delivered hyaluronidase, an enzyme that breaks down tight tissue, directly into the skin. The goal was to improve mouth opening for eating, speaking, and oral care. Results were measured by changes in mouth opening and patient-reported quality of life.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Locations
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Nebraska Medicine, Dermatology Westroads
Omaha, Nebraska, 68114, United States
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University of Nebraska Medical Center, Lauritzen Outpatient Center
Omaha, Nebraska, 68105, United States