University Of Nebraska

This study tests whether using a special PET scan (PSMA-PET) to guide radiation can safely reduce the dose and side effects in men whose prostate cancer has returned after surgery. About 54 men will receive a lower amount of radiation to the pelvis plus a focused boost to the can…

This study compares two ways to stop metastatic brain tumors from coming back after surgery. One group gets a chemotherapy wafer (GLIADEL) placed in the brain during tumor removal, while the other gets radiation within six weeks after surgery. About 100 adults with up to four bra…

This early study tests whether tamoxifen, a drug used for breast cancer, can shrink or stabilize pancreatic cysts that may turn into cancer. Up to 15 women with these cysts who are not having surgery right away will take tamoxifen daily for up to 24 weeks. The main goal is to see…

This study is for men with prostate cancer that has spread to pelvic lymph nodes only detectable by a special PSMA-PET scan. It compares standard hormone therapy plus radiation to a stronger combination that includes abiraterone and prednisone. The goal is to see if the stronger …

This study tests a new way to give radiation for prostate cancer that has not spread. It combines two types of radiation: one placed directly into the prostate and another aimed at the prostate and nearby lymph nodes from outside the body. The goal is to see if this approach is s…

This study tests whether a lower dose of a standard drug (cyclophosphamide) can prevent graft-versus-host disease just as well as the usual dose, but with fewer side effects and better quality of life. It involves 126 adults aged 60 and older who are getting a stem cell transplan…

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a fast-growing brain tumor) has returned after standard treatments. The drugs are temozolomide (given in low, frequent doses) and abexinostat (an experimental pill). The main goal is to fi…

This study explores whether measuring pulse arrival time in arms and legs can detect peripheral artery disease (PAD) as accurately as the standard ankle-brachial index test. About 40 adults with or without PAD will have both tests during a single 2.5-hour lab visit. If successful…

This study aims to increase colorectal cancer screening among African Americans, who face higher risks and lower screening rates. About 1,200 participants aged 45-75 will receive a free at-home test kit, educational materials, and reminders. Some will also see targeted social med…

This study tests if at-home lower-body heat therapy can improve walking ability and overall health in people aged 50-90 with long COVID. Participants will use heat sessions to see if it eases fatigue and physical decline. The goal is to find a simple, accessible way to help those…

This study tests whether a daily nasal spray of oxytocin, a natural hormone, can lower stress and improve quality of life in female family caregivers of people with dementia. About 32 women aged 50 and older who provide unpaid care will receive either a low dose, a higher dose, o…

This study tests a mobile app called Family Room designed to help family caregivers of ICU patients feel more involved and less stressed. About 100 caregivers will either use the app or receive standard care, and their well-being and satisfaction will be measured through surveys.…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve memory in healthy young adults, healthy older adults, and older adults with amnestic mild cognitive impairment (aMCI), a condition that often…

This study tests a training program for caregivers of adolescents (ages 10-17) with profound autism. The training teaches caregivers how to use picture-based activity schedules so their child can do tasks independently for short periods. The goal is to give caregivers more time f…

This study tests whether a single dose of the drug Vumerity can improve blood vessel function and walking ability in people with peripheral artery disease (PAD). Researchers will give 20 adults aged 50-75 either Vumerity or a placebo and measure changes in blood flow, oxygen use,…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce severe leg pain and improve blood flow in people with both painful diabetic neuropathy and peripheral artery disease. Fifteen adults who already have a permanent s…

This study tests whether the antidepressant escitalopram can improve memory, focus, and overall thinking in people newly diagnosed with a fast-growing brain cancer (grade IV glioma). About 20 participants will take the drug for 17 weeks and complete thinking and mood tests. The g…

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study looks at whether meeting with a coach—either in person or by video—helps adults with a type of heart failure (HFpEF) exercise more regularly. 300 participants will be split into three groups for 18 months: one with no coach, one with in-person coaching, and one with vi…

This study tests whether a set of recovery steps called ERAS can help people who have breast-conserving surgery for breast cancer. The goal is to control pain with fewer opioids and improve recovery. About 260 adults will be randomly assigned to receive either the ERAS plan or st…

This study tests whether taking MitoQ for six months can improve walking ability and reduce leg pain in people with peripheral artery disease (PAD). Researchers will measure walking distance on a treadmill and during a 6-minute walk, as well as daily activity and quality of life.…

This study looks at how brain tumors affect areas of the brain that control movement, sensation, and speech. Researchers will use special scans before, during, and after surgery to see how the brain reorganizes itself. The goal is to better understand brain plasticity and improve…

This study looks at whether six weeks of group therapy can change the gut microbiome in women with chronic stress. About 30 women will answer stress questionnaires and mail in stool samples before and after the therapy sessions. The goal is to understand the link between stress, …

This study follows 1250 people at higher risk for pancreas cancer—such as those with new diabetes, pancreas cysts, or a family history—to find early warning signs in the blood. Participants visit Omaha twice a year to give blood samples. The goal is to develop a screening test th…

This study looks at how well the mouth heals after a tooth extraction in younger (14-18) and older (50-80) adults. Half of the participants will get a treatment made from their own blood, called platelet-rich fibrinogen, placed in the extraction site. Researchers will compare hea…

This study looks at whether giving ICU staff real-time feedback and having a dedicated nurse facilitator can increase the use of a set of proven practices (the ABCDEF bundle) for adults on breathing machines. About 8,100 patients across multiple ICUs will take part. The goal is t…

This study looks at how inflammation in the gums affects the body's immune response during healing after a tooth is removed. Researchers will measure gum health before extraction, take small tissue samples right after and again two weeks later, and check healing at three months. …

This study looks at whether LASIK or similar eye surgeries affect the results of OCT scans, which are used to monitor conditions like glaucoma. About 33 people who are getting refractive surgery will have their eyes measured before and after the procedure. The goal is to help doc…

This study looks at how using a 3D-printed prosthetic hand changes brain activity in children born with missing fingers, hands, or arms. Researchers will use a special brain scanner to measure brain responses while children perform tasks with the prosthetic. The goal is to learn …

This study looks at how deep brain stimulation (DBS) changes the way people with Parkinson's disease, essential tremor, or dystonia pay attention and perceive emotions in others' faces. Researchers will track eye movements and ask participants to rate facial expressions before, d…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…